Direct Cell Radiolabeling for in Vivo Cell Tracking with PET and SPECT Imaging

PJ Gawne, F Man, PJ Blower… - Chemical reviews, 2022 - ACS Publications
The arrival of cell-based therapies is a revolution in medicine. However, its safe clinical
application in a rational manner depends on reliable, clinically applicable methods for …

Cellular kinetics: A clinical and computational review of CAR-T cell pharmacology

T Qi, K McGrath, R Ranganathan, G Dotti… - Advanced drug delivery …, 2022 - Elsevier
To the extent that pharmacokinetics influence the effectiveness of nonliving therapeutics, so
too do cellular kinetics influence the efficacy of Chimeric Antigen Receptor (CAR)-T cell …

The future of regulatory T cell therapy: promises and challenges of implementing CAR technology

YR Mohseni, SL Tung, C Dudreuilh, RI Lechler… - Frontiers in …, 2020 - frontiersin.org
Cell therapy with polyclonal regulatory T cells (Tregs) has been translated into the clinic and
is currently being tested in transplant recipients and patients suffering from autoimmune …

Expanding theranostic radiopharmaceuticals for tumor diagnosis and therapy

C Barca, CM Griessinger, A Faust, D Depke, M Essler… - Pharmaceuticals, 2021 - mdpi.com
Radioligand theranostics (RT) in oncology use cancer-type specific biomarkers and
molecular imaging (MI), including positron emission tomography (PET), single-photon …

[HTML][HTML] Spatiotemporal PET imaging reveals differences in CAR-T tumor retention in triple-negative breast cancer models

A Volpe, C Lang, L Lim, F Man, E Kurtys… - Molecular Therapy, 2020 - cell.com
Chimeric antigen receptor T cell therapy (CAR-T) has been rolled out as a new treatment for
hematological malignancies. For solid tumor treatment, CAR-T has been disappointing so …

Carbon-11: radiochemistry and target-based PET molecular imaging applications in oncology, cardiology, and neurology

NS Goud, A Bhattacharya, RK Joshi… - Journal of Medicinal …, 2021 - ACS Publications
The positron emission tomography (PET) molecular imaging technique has gained its
universal value as a remarkable tool for medical diagnosis and biomedical research …

The sodium iodide symporter (NIS): novel applications for radionuclide imaging and treatment

C Spitzweg, PJ Nelson, E Wagner… - Endocrine-related …, 2021 - erc.bioscientifica.com
Cloning of the sodium iodide symporter (NIS) 25 years ago has opened an exciting chapter
in molecular thyroidology with the characterization of NIS as one of the most powerful …

Near-infrared fluorescent Aza-BODIPY dyes: Rational structural design and biomedical imaging

B Zhao, L Liao, Y Zhu, Z Hu, F Wu - Journal of Luminescence, 2023 - Elsevier
Near-infrared dyes have attracted widespread attention due to their intense absorption and
emission in the near-infrared region. As an important class of heteroatom-containing …

Zirconium immune-complexes for PET molecular imaging: current status and prospects

L Melendez-Alafort, G Ferro-Flores, L De Nardo… - Coordination Chemistry …, 2023 - Elsevier
Diagnostic molecular images, obtained by positron emission tomography (PET), have
successfully functioned as sensitive tools for detecting and monitoring the treatment of …

Radiolabelling of Polyclonally Expanded Human Regulatory T Cells (Treg) with 89Zr-oxine for Medium-Term In Vivo Cell Tracking

J Jacob, A Volpe, Q Peng, RI Lechler, LA Smyth… - Molecules, 2023 - mdpi.com
Regulatory T cells (Tregs) are a promising candidate cell therapy to treat autoimmune
diseases and aid the longevity of transplanted solid organs. Despite increasing numbers of …