Size at birth is a critical determinant of life expectancy, and is dependent primarily on the
placental supply of nutrients. However, the placenta is not just a passive organ for the …

Poor environmental conditions, including malnutrition, hypoxia and obesity in the mother
increase the risk of pregnancy complications, such as pre-eclampsia and gestational …

Placental ischemia is believed to be the initial event in the development of preeclampsia.
Mitochondrial dysfunction is a cause of reactive oxygen species (ROS) generation and …

Aim The current study investigated the impact of maternal obesity on placental phenotype in
relation to fetal growth and sex. Methods Female C57BL6/J mice were fed either a diet high …

Mitochondria respond to a range of stimuli and function in energy production and redox
homeostasis. However, little is known about the developmental and environmental control of …

Key points Maternal protein restriction during pregnancy increases both maternal and
offspring oxidative stress and leads to metabolic dysfunction. Maternal low protein diet …

The development of the fetal heart is exquisitely controlled by a multitude of factors, ranging
from humoral to mechanical forces. The gatekeeper regulating many of these factors is the …

A lipotoxic placental environment is recognized in maternal obesity, with increased
inflammation and oxidative stress. These changes might alter mitochondrial function, with …

Contents The placenta is a dynamic, metabolically active organ with significant nutrient and
energy requirements for growth, nutrient transfer and protein synthesis. It uses a range of …

Mechanisms of resource allocation are essential for maternal and fetal survival, particularly
when the availability of nutrients is limited. We investigated the responses of feto-placental …