Conspectus Platinum-based anticancer drugs are the mainstay of chemotherapy regimens
in clinic. Nevertheless, the efficacy of platinum drugs is badly affected by serious systemic …

Cisplatin is a widely used chemotherapeutic agent that is clinically approved to fight both
carcinomas and sarcomas. It has relatively high efficiency in treating ovarian cancers and …

Ovarian cancer is characterized by dysbiosis, referred to as oncobiosis in neoplastic
diseases. In ovarian cancer, oncobiosis was identified in numerous compartments, including …

Intein-mediated protein splicing has become an essential tool in modern biotechnology.
Fundamental progress in the structure and catalytic strategies of cis-and trans-splicing …

Approximately 100 million people worldwide are affected by M. Tuberculosis (Mtb), a
contagious disease which causes death in humans and is considered to be quite deadly …

Inteins are mobile genetic elements that apply standard enzymatic strategies to excise
themselves post-translationally from the precursor protein via protein splicing. Since their …

Rapid and efficient tag removal remains a significant problem in recombinant protein
purification. Using an engineered DnaE intein from Nostoc punctiforme, we developed a …

Multidrug-resistant pathogens are of significant concern in recent years. Hence new
antifungal and anti-bacterial drug targets are urgently needed before the situation goes …

The toxicity of and resistance to platinum complexes as cisplatin, oxaliplatin or carboplatin
calls for the replacement of these therapeutic agents in clinical settings. We have previously …

Self-splicing proteins, called inteins, are present in many human pathogens, including the
emerging fungal threats Cryptococcus neoformans (Cne) and Cryptococcus gattii (Cga), the …