The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway
is an evolutionarily conserved mechanism of transmembrane signal transduction that …

The Janus kinase-signal transducer and transcription activator pathway (JAK-STAT) serves
as a cornerstone in cellular signaling, regulating physiological and pathological processes …

A lack of models that recapitulate the complexity of human bone marrow has hampered
mechanistic studies of normal and malignant hematopoiesis and the validation of novel …

Endothelial cells (ECs) that line vascular and lymphatic vessels are being increasingly
recognized as important to organ function in health and disease. ECs participate not only in …

Reversal of ischemia is mediated by neo-angiogenesis requiring endothelial cell (EC) and
pericyte interactions to form stable microvascular networks. We describe an unrecognized …

The neonate with low birth weight (LBW) resulted from intrauterine growth retardation
(IUGR) exists a substantial risk of postpartum death. Placental insufficiency is responsible for …

Rheumatoid arthritis (RA) is a highly prevalent autoimmune disorder. The pathogenesis of
the disease is complex and involves various cellular populations, including fibroblast-like …

Stem cell transplantation presents a potentially curative strategy for genetic disorders of
skeletal muscle, but this approach is limited by the deleterious effects of cell expansion in …

The adhesion and subsequent activation of T cells is a critical step in local inflammatory
responses, particularly of alloreactive leukocytes in rejection of transplanted donor tissue …

Blood endothelial cells actively regulate egress of leukocytes into peripheral tissues in
response to inflammatory insult. The resolution of inflammation is critical for healing and …