Pyridine: the scaffolds with significant clinical diversity

S De, AK SK, SK Shah, S Kazi, N Sarkar, S Banerjee… - Rsc Advances, 2022 - pubs.rsc.org
The nitrogen-bearing heterocycle pyridine in its several analogous forms occupies an
important position as a precious source of clinically useful agents in the field of medicinal …

Metal-free multicomponent syntheses of pyridines

C Allais, JM Grassot, J Rodriguez… - Chemical …, 2014 - ACS Publications
They react according to a succession of mono-or bimolecular processes to form at the end
one product that incorporates important portions and functionalities of the starting materials …

A comprehensive review of topoisomerase inhibitors as anticancer agents in the past decade

X Liang, Q Wu, S Luan, Z Yin, C He, L Yin, Y Zou… - European journal of …, 2019 - Elsevier
The topoisomerase enzymes play an important role in DNA metabolism, and searching for
enzyme inhibitors is an important target in the search for new anticancer drugs. Discovery of …

Environmentally benign synthesis of heterocyclic compounds by combined microwave-assisted heterogeneous catalytic approaches

A Daştan, A Kulkarni, B Török - Green chemistry, 2012 - pubs.rsc.org
Recent advances in the application of heterogeneous catalysis combined with microwave
irradiation in the synthesis of heterocyclic compounds are reviewed. While a detailed …

Synthesis and anti-tumor activities of some new pyridines and pyrazolo [1, 5-a] pyrimidines

OM Ahmed, MA Mohamed, RR Ahmed… - European journal of …, 2009 - Elsevier
Cyclocondensation of cyanoacetamide, cyanothioacetamide and 3-aminopyrazols with
sodium salt of 3-hydroxy-1-(2-naphthyl) prop-2-en-1-one gives pyridin-2-one, pyridin-2 (1H) …

[PDF][PDF] Synthesis,(in vitro) antitumor and antimicrobial activity of some pyrazoline, pyridine, and pyrimidine derivatives linked to indole moiety

E Nassar - J. Am. Sci, 2010 - academia.edu
Aldol condensation reaction between 3-indolaldehyde 1 and 4-methoxyacetophenone 2
afforded chalcone compounds 3. This compound was reacted with some different reagents …

One‐pot synthesis of new thiadiazolyl‐pyridines as anticancer and antioxidant agents

SM Gomha, ZA Muhammad… - Journal of …, 2018 - Wiley Online Library
The reaction of one equivalents of 5‐acetylthiadiazole with one equivalent of aldehyde in
acetic acid and ammonium acetate yielded thiadiazolyl‐pyridine derivatives in a …

Design, synthesis, antimicrobial evaluation, and molecular docking study of some 4-thiazolidinone derivatives containing pyridine and quinazoline moiety

NC Desai, KA Jadeja, DJ Jadeja… - Synthetic …, 2021 - Taylor & Francis
Abstract A series of 5-aryl-3-(4-oxo-2-phenylquinazolin-3 (4 H)-yl)-2-(pyridin-4-yl) thiazolidin-
4-ones were synthesized and evaluated for their antibacterial and antifungal activities …

Bis-tridentate N-heterocyclic carbene Ru (II) complexes are promising new agents for photodynamic therapy

RT Ryan, KC Stevens, R Calabro, S Parkin… - Inorganic …, 2020 - ACS Publications
Ruthenium (II) complexes developed for photodynamic therapy (PDT) are almost exclusively
tris-bidentate systems with C2 or D 3 symmetry. This is due to the fact that this structural …

Synthesis and biological evaluation of new pyridines containing imidazole moiety as antimicrobial and anticancer agents

I Abbas, S Gomha, M Elaasser… - Turkish Journal of …, 2015 - journals.tubitak.gov.tr
The synthesis of a novel series of pyridine and bipyridine derivatives is described via one-
pot multicomponent reaction of 5-acetylimidazole, malonitrile (or ethylcyanoacetate or …