Untangling the sequence of events during the S2 → S3 transition in photosystem II and implications for the water oxidation mechanism
In oxygenic photosynthesis, light-driven oxidation of water to molecular oxygen is carried out
by the oxygen-evolving complex (OEC) in photosystem II (PS II). Recently, we reported the …
by the oxygen-evolving complex (OEC) in photosystem II (PS II). Recently, we reported the …
Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook
Serial femtosecond crystallography (SFX) revolutionized macromolecular crystallography
over the past decade by enabling the collection of X-ray diffraction data from nano-or …
over the past decade by enabling the collection of X-ray diffraction data from nano-or …
Structural dynamics in the water and proton channels of photosystem II during the S2 to S3 transition
Light-driven oxidation of water to molecular oxygen is catalyzed by the oxygen-evolving
complex (OEC) in Photosystem II (PS II). This multi-electron, multi-proton catalysis requires …
complex (OEC) in Photosystem II (PS II). This multi-electron, multi-proton catalysis requires …
Structure of a ribonucleotide reductase R2 protein radical
H Lebrette, V Srinivas, J John, O Aurelius, R Kumar… - Science, 2023 - science.org
Aerobic ribonucleotide reductases (RNRs) initiate synthesis of DNA building blocks by
generating a free radical within the R2 subunit; the radical is subsequently shuttled to the …
generating a free radical within the R2 subunit; the radical is subsequently shuttled to the …
Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing
The COVID-19 pandemic has resulted in 198 million reported infections and more than 4
million deaths as of July 2021 (covid19. who. int). Research to identify effective therapies for …
million deaths as of July 2021 (covid19. who. int). Research to identify effective therapies for …
High-resolution XFEL structure of the soluble methane monooxygenase hydroxylase complex with its regulatory component at ambient temperature in two oxidation …
V Srinivas, R Banerjee, H Lebrette… - Journal of the …, 2020 - ACS Publications
Soluble methane monooxygenase (sMMO) is a multicomponent metalloenzyme that
catalyzes the conversion of methane to methanol at ambient temperature using a nonheme …
catalyzes the conversion of methane to methanol at ambient temperature using a nonheme …
Advances in diffraction studies of light-induced transient species in molecular crystals and selected complementary techniques
The review provides a summary of the current methods of tracing photoexcitation processes
and structural dynamics in the solid state, putting major emphasis on the X-ray diffraction …
and structural dynamics in the solid state, putting major emphasis on the X-ray diffraction …
Heterogeneity in M. tuberculosis β-lactamase inhibition by Sulbactam
For decades, researchers have elucidated essential enzymatic functions on the atomic
length scale by tracing atomic positions in real-time. Our work builds on possibilities …
length scale by tracing atomic positions in real-time. Our work builds on possibilities …
Changes in an enzyme ensemble during catalysis observed by high-resolution XFEL crystallography
N Smith, M Dasgupta, DC Wych, C Dolamore… - Science …, 2024 - science.org
Enzymes populate ensembles of structures necessary for catalysis that are difficult to
experimentally characterize. We use time-resolved mix-and-inject serial crystallography at …
experimentally characterize. We use time-resolved mix-and-inject serial crystallography at …
[PDF][PDF] High-viscosity sample-injection device for serial femtosecond crystallography at atmospheric pressure
Y Shimazu, K Tono, T Tanaka… - Journal of applied …, 2019 - journals.iucr.org
A sample-injection device has been developed at SPring-8 Angstrom Compact Free-
Electron Laser (SACLA) for serial femtosecond crystallography (SFX) at atmospheric …
Electron Laser (SACLA) for serial femtosecond crystallography (SFX) at atmospheric …