The mechanisms of integral membrane protein biogenesis
RS Hegde, RJ Keenan - Nature reviews Molecular cell biology, 2022 - nature.com
Roughly one quarter of all genes code for integral membrane proteins that are inserted into
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …
the plasma membrane of prokaryotes or the endoplasmic reticulum membrane of …
Drug combinations: a strategy to extend the life of antibiotics in the 21st century
Antimicrobial resistance threatens a resurgence of life-threatening bacterial infections and
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …
the potential demise of many aspects of modern medicine. Despite intensive drug discovery …
The IntAct database: efficient access to fine-grained molecular interaction data
N Del Toro, A Shrivastava, E Ragueneau… - Nucleic acids …, 2022 - academic.oup.com
The IntAct molecular interaction database (https://www. ebi. ac. uk/intact) is a curated
resource of molecular interactions, derived from the scientific literature and from direct data …
resource of molecular interactions, derived from the scientific literature and from direct data …
[HTML][HTML] Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
Thousands of interactions assemble proteins into modules that impart spatial and functional
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
CORUM: the comprehensive resource of mammalian protein complexes—2019
M Giurgiu, J Reinhard, B Brauner… - Nucleic acids …, 2019 - academic.oup.com
CORUM is a database that provides a manually curated repository of experimentally
characterized protein complexes from mammalian organisms, mainly human (67%), mouse …
characterized protein complexes from mammalian organisms, mainly human (67%), mouse …
Architecture of the human interactome defines protein communities and disease networks
The physiology of a cell can be viewed as the product of thousands of proteins acting in
concert to shape the cellular response. Coordination is achieved in part through networks of …
concert to shape the cellular response. Coordination is achieved in part through networks of …
Modeling protein quaternary structure of homo-and hetero-oligomers beyond binary interactions by homology
Cellular processes often depend on interactions between proteins and the formation of
macromolecular complexes. The impairment of such interactions can lead to deregulation of …
macromolecular complexes. The impairment of such interactions can lead to deregulation of …
Endoribonucleolytic cleavage of m6A-containing RNAs by RNase P/MRP complex
Summary N 6-methyladenosine (m 6 A) is the most abundant internal modification in RNAs
and plays regulatory roles in a variety of biological and physiological processes. Despite its …
and plays regulatory roles in a variety of biological and physiological processes. Despite its …
A global genetic interaction network maps a wiring diagram of cellular function
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
The social and structural architecture of the yeast protein interactome
Cellular functions are mediated by protein–protein interactions, and mapping the
interactome provides fundamental insights into biological systems. Affinity purification …
interactome provides fundamental insights into biological systems. Affinity purification …