Leptin, a hormone that is capable of effectively reducing food intake and body weight, was
initially considered for use in the treatment of obesity. However, obese subjects have since …

The hyperphagia, low sympathetic nervous system tone, and decreased circulating
concentrations of bioactive thyroid hormones that are common to states of congenital leptin …

Rodent models of obesity induced by consuming high-fat diet (HFD) are characterized by
inflammation both in peripheral tissues and in hypothalamic areas critical for energy …

Maintaining healthy body weight is increasingly difficult in our obesogenic environment.
Dieting efforts are often overpowered by the internal drive to consume energy-dense foods …

Maintenance of a reduced body weight is accompanied by a decrease in energy
expenditure beyond that accounted for by reduced body mass and composition, as well as …

Calorie restriction (CR) is the most potent, non-pharmacological intervention to support
metabolic health. The effects of calorie restriction exceed weight loss. Consistent throughout …

成人的体重既不是恒定的也不会发生单向改变, 体重通常是围绕着一个“设定点” 上下波动,
即处于所谓“内稳状态” 的动态平衡. 两类因素决定了体重的改变方向, 其中使体重偏离其设定点 …

Introduction: Obesity is a body weight disorder characterized by excess adiposity that
increases the risk for developing co-morbidities such as type 2 diabetes. A large medical …

Body weight is determined via both metabolic and hedonic mechanisms. Metabolic
regulation of body weight centres around the 'body weight set point', which is programmed …

Mammals regulate fat mass so that increases or reductions in adipose tissue mass activate
responses that favor return to one's previous weight. A reduction in fat mass activates a …