Idiopathic pulmonary fibrosis (IPF) is a progressive, lethal fibrotic lung disease that occurs
primarily in middle-aged and elderly adults. It is a major cause of morbidity and mortality …

Idiopathic pulmonary fibrosis (IPF) is a fatal age-associated disease that is characterized by
progressive and irreversible scarring of the lung. The pathogenesis of IPF is not completely …

Fibrosis, a process caused by excessive deposition of extracellular matrix (ECM), is a
common cause and outcome of organ failure and even death. Researchers have made …

Background and aims Scar tissue accumulation in organs is the underlying cause of many
fibrotic diseases. Due to the extensive array of organs affected, the long-term nature of …

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disorder
showcasing an interaction between genetic predisposition and environmental risks. This …

Fibrosis contributes to the development of many diseases and many target molecules are
involved in fibrosis. Currently, the majority of fibrosis treatment strategies are limited to …

Acute kidney injury (AKI) and progressive chronic kidney disease (CKD) are intrinsically tied
syndromes. In this regard, the acutely injured kidney often does not achieve its full …

The gain-of-function mucin 5B (MUC5B) promoter variant, rs35705950, confers the largest
risk, genetic or otherwise, for the development of idiopathic pulmonary fibrosis; however, the …

Mesenchymal cells in the lung are crucial during development, but also contribute to the
pathogenesis of fibrotic disorders, including idiopathic pulmonary fibrosis (IPF), the most …

Progressive tissue fibrosis, including idiopathic pulmonary fibrosis (IPF), is characterized by
excessive recruitment of fibroblasts to sites of tissue injury and unremitting extracellular …