The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

The importance of mitochondria for a typical aerobic eukaryotic cell is undeniable, as the list
of necessary mitochondrial processes is steadily growing. Here, we summarize the current …

The endoplasmic reticulum–mitochondria encounter structure (ERMES) connects the
mitochondrial outer membrane with the ER. Multiple functions have been linked to ERMES …

Trypanosoma brucei is a unicellular parasite that causes devastating diseases in humans
and animals. It diverged from most other eukaryotes very early in evolution and, as a …

Mitochondria are essential for eukaryotic life and more than 95% of their proteins are
imported as precursors from the cytosol. The targeting signals for this posttranslational …

The evolution of mitochondrial protein import and the systems that mediate it marks the
boundary between the endosymbiotic ancestor of mitochondria and a true organelle that is …

The two-partner secretion (TPS) pathway is a branch of type V secretion. TPS systems are
dedicated to the secretion across the outer membrane of long proteins that form extended β …

Membrane proteins evolved to reside in the hydrophobic lipid bilayers of cellular
membranes. Therefore, membrane proteins bridge the different aqueous compartments …

Mitochondrial protein import is essential for all eukaryotes and mediated by hetero-
oligomeric protein translocases thought to be conserved within all eukaryotes. We have …

Mitochondria have many different functions, the most important one of which is oxidative
phosphorylation. They originated from an endosymbiotic event between a bacterium and an …