Peptide-drug conjugates and their targets in advanced cancer therapies

P Hoppenz, S Els-Heindl, AG Beck-Sickinger - Frontiers in chemistry, 2020 - frontiersin.org
Cancer became recently the leading cause of death in industrialized countries. Even though
standard treatments achieve significant effects in growth inhibition and tumor elimination …

GnRH and GnRH receptors in the pathophysiology of the human female reproductive system

R Maggi, AM Cariboni, MM Marelli… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND Human reproduction depends on an intact hypothalamic–pituitary–gonadal
(HPG) axis. Hypothalamic gonadotrophin-releasing hormone (GnRH) has been recognized …

The Concise Guide to PHARMACOLOGY 2013/14: G protein‐coupled receptors

SPH Alexander, HE Benson… - British journal of …, 2013 - Wiley Online Library
Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Actions of bisphenol A and bisphenol S on the reproductive neuroendocrine system during early development in zebrafish

W Qiu, Y Zhao, M Yang, M Farajzadeh, C Pan… - …, 2016 - academic.oup.com
Bisphenol A (BPA) is a well-known environmental, endocrine-disrupting chemical, and
bisphenol S (BPS) has been considered a safer alternative for BPA-free products. The …

Insights into thymic aging and regeneration

DD Taub, DL Longo - Immunological reviews, 2005 - Wiley Online Library
The deterioration of the immune system with progressive aging is believed to contribute to
morbidity and mortality in elderly humans due to the increased incidence of infection …

A review of the current status of siRNA nanomedicines in the treatment of cancer

P Resnier, T Montier, V Mathieu, JP Benoit, C Passirani - Biomaterials, 2013 - Elsevier
RNA interference currently offers new opportunities for gene therapy by the specific
extinction of targeted gene (s) in cancer diseases. However, the main challenge for nucleic …

GPCR-I-TASSER: a hybrid approach to G protein-coupled receptor structure modeling and the application to the human genome

J Zhang, J Yang, R Jang, Y Zhang - Structure, 2015 - cell.com
Experimental structure determination remains difficult for G protein-coupled receptors
(GPCRs). We propose a new hybrid protocol to construct GPCR structure models that …

Ovarian protection with gonadotropin-releasing hormone agonists during chemotherapy in cancer patients: from biological evidence to clinical application

M Lambertini, F Horicks, L Del Mastro… - Cancer treatment …, 2019 - Elsevier
Survivorship issues are an area of crucial importance to be addressed as early as possible
by all health care providers dealing with cancer patients. In women diagnosed during their …

Mechanisms of neurotoxicity associated with exposure to the herbicide atrazine

SC Stradtman, JL Freeman - Toxics, 2021 - mdpi.com
Atrazine is an herbicide commonly used on crops to prevent broadleaf weeds. Atrazine is an
endocrine-disrupting chemical mainly targeting the neuroendocrine system and associated …

How to preserve fertility in young women exposed to chemotherapy? The role of GnRH agonist cotreatment in addition to cryopreservation of embrya, oocytes, or …

Z Blumenfeld - The oncologist, 2007 - academic.oup.com
Learning Objectives After completing this course, the reader will be able to: Discuss the
possibilities for preserving fertility in women exposed to chemotherapy. List the possible …