Insights into the structure, function, and ligand discovery of the large neutral amino acid transporter 1, LAT1

N Singh, GF Ecker - International journal of molecular sciences, 2018 - mdpi.com
The large neutral amino acid transporter 1 (LAT1, or SLC7A5) is a sodium-and pH-
independent transporter, which supplies essential amino acids (eg, leucine, phenylalanine) …

Translocator protein 18 kDa (TSPO): an old protein with new functions?

F Li, J Liu, N Liu, LA Kuhn, RM Garavito… - Biochemistry, 2016 - ACS Publications
Translocator protein 18 kDa (TSPO) was previously known as the peripheral
benzodiazepine receptor (PBR) in eukaryotes, where it is mainly localized to the …

Comparative protein structure modeling using MODELLER

B Webb, A Sali - Current protocols in bioinformatics, 2016 - Wiley Online Library
Comparative protein structure modeling predicts the three‐dimensional structure of a given
protein sequence (target) based primarily on its alignment to one or more proteins of known …

Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation

K Morita, Y Hama, T Izume, N Tamura, T Ueno… - Journal of Cell …, 2018 - rupress.org
Macroautophagy is an intracellular degradation process that requires multiple autophagy-
related (ATG) genes. In this study, we performed a genome-wide screen using the …

CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor

CJ Shoemaker, TQ Huang, NR Weir, NJ Polyakov… - PLoS …, 2019 - journals.plos.org
The power of forward genetics in yeast is the foundation on which the field of autophagy
research firmly stands. Complementary work on autophagy in higher eukaryotes has …

The alternating-access mechanism of MFS transporters arises from inverted-topology repeats

S Radestock, LR Forrest - Journal of molecular biology, 2011 - Elsevier
Lactose permease (LacY) is the prototype of the major facilitator superfamily (MFS) of
secondary transporters. Available structures of LacY reveal a state in which the substrate is …

Structural symmetry in membrane proteins

LR Forrest - Annual review of biophysics, 2015 - annualreviews.org
Symmetry is a common feature among natural systems, including protein structures. A strong
propensity toward symmetric architectures has long been recognized for water-soluble …

A role for diatom-like silicon transporters in calcifying coccolithophores

GM Durak, AR Taylor, CE Walker, I Probert… - Nature …, 2016 - nature.com
Biomineralization by marine phytoplankton, such as the silicifying diatoms and calcifying
coccolithophores, plays an important role in carbon and nutrient cycling in the oceans …

Molecular modeling and ligand docking for solute carrier (SLC) transporters

A Schlessinger, N Khuri… - Current topics in …, 2013 - ingentaconnect.com
Solute Carrier (SLC) transporters are membrane proteins that transport solutes, such as
ions, metabolites, peptides, and drugs, across biological membranes, using diverse energy …

Heteromeric solute carriers: function, structure, pathology and pharmacology

SJ Fairweather, N Shah, S Brӧer - Protein Reviews: Volume 21, 2021 - Springer
Solute carriers form one of three major superfamilies of membrane transporters in humans,
and include uniporters, exchangers and symporters. Following several decades of …