[HTML][HTML] Smokeless tobacco (paan and gutkha) consumption, prevalence, and contribution to oral cancer

K Niaz, F Maqbool, F Khan, H Bahadar… - Epidemiology and …, 2017 - ncbi.nlm.nih.gov
Smokeless tobacco consumption, which is widespread throughout the world, leads to oral
submucous fibrosis (OSMF), which is a long-lasting and devastating condition of the oral …

Analysis of a form of oxidative DNA damage, 8-hydroxy-2′-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis

H Kasai - Mutation Research/Reviews in Mutation Research, 1997 - Elsevier
8-hydroxy-2′-deoxyguanosine (8-OH-dG) was first reported in 1984 as a major form of
oxidative DNA damage product by heated sugar, Fenton-type reagents and X-irradiation in …

Alert for an epidemic of oral cancer due to use of the betel quid substitutes gutkha and pan masala: a review of agents and causative mechanisms

U Nair, H Bartsch, J Nair - Mutagenesis, 2004 - academic.oup.com
Abstract In south‐east Asia, Taiwan and Papua New Guinea, smoking, alcohol consumption
and chewing of betel quid with or without tobacco or areca nut with or without tobacco are …

Role of areca nut in betel quid-associated chemical carcinogenesis: current awareness and future perspectives

JH Jeng, MC Chang, LJ Hahn - Oral oncology, 2001 - Elsevier
Betel quid (BQ)-chewing is a popular oral habit with potential links to the occurrence of oral
cancer. Many of the literature-based studies reveal that areca nut (AN) extract may …

Association of betel nut with carcinogenesis: revisit with a clinical perspective

RN Sharan, R Mehrotra, Y Choudhury, K Asotra - 2012 - journals.plos.org
Betel nut (BN), betel quid (BQ) and products derived from them are widely used as a socially
endorsed masticatory product. The addictive nature of BN/BQ has resulted in its widespread …

Carcinogen-mediated oxidant formation and oxidative DNA damage

K Frenkel - Pharmacology & therapeutics, 1992 - Elsevier
This article reviews the experimental data that points to formation of reactive oxygen species
(ROS) and oxidative DNA base damage as being important contributors to cancer …

Characterization of the differentiated antioxidant profile of human saliva

RM Nagler, I Klein, N Zarzhevsky, N Drigues… - Free Radical Biology …, 2002 - Elsevier
Saliva is armed with various defense mechanisms, such as the immunological and
enzymatic defense systems. In addition, saliva has the ability to protect the mucosa against …

Oxidative and antioxidative mechanisms in oral cancer and precancer: a review

SK Choudhari, M Chaudhary, AR Gadbail, A Sharma… - Oral oncology, 2014 - Elsevier
Development of cancer in humans is a multistep process. Complex series of cellular and
molecular changes participating in cancer development are mediated by a diversity of …

Roles of keratinocyte inflammation in oral cancer: regulating the prostaglandin E 2 , interleukin-6 and TNF-α production of oral epithelial cells by areca …

JH Jeng, YJ Wang, BL Chiang, PH Lee… - …, 2003 - academic.oup.com
Betel quid (BQ) chewing is an etiologic factor of oral cancer and submucus fibrosis (OSF).
Keratinocyte inflammation is crucial for the pathogenesis of cancer and tissue fibrosis. We …

Areca nut extract and arecoline induced the cell cycle arrest but not apoptosis of cultured oral KB epithelial cells: association of glutathione, reactive oxygen species …

MC Chang, YS Ho, PH Lee, CP Chan, JJ Lee… - …, 2001 - academic.oup.com
There are 600 million betel quid (BQ) chewers in the world. BQ chewing is a major etiologic
factor of oral cancer. Areca nut (AN) and arecoline may inhibit the growth of oral mucosal …