Fungal unspecific peroxygenases (UPOs) are among the most promising biocatalysts in
synthetic chemistry. The kaleidoscope of oxyfunctionalization reactions that are of industrial …

The selective insertion of oxygen into non-activated organic molecules has to date been
considered of utmost importance to synthesize existing and next generation industrial …

The effective design of combinatorial libraries to balance fitness and diversity facilitates the
engineering of useful enzyme functions, particularly those that are poorly characterized or …

Given prominent physicochemical similarities between H2O2 and water, we report a new
strategy for promoting the peroxygenase activity of P450 enzymes by engineering their …

Enzymatic hydroxylation of activated and nonactivated sp3-carbons attracts keen interest
from the chemistry community as it is one of the most challenging tasks in organic synthesis …

Unspecific peroxygenases (UPOs), whose sequences can be found in the genomes of
thousands of filamentous fungi, many yeasts and certain fungus-like protists, are fascinating …

New-to-nature radical biocatalysis has recently emerged as a powerful strategy to tame
fleeting open-shell intermediates for stereoselective transformations. In 2021, we introduced …

Unspecific peroxygenases (UPOs) perform oxyfunctionalizations for a wide range of
substrates utilizing H2O2 without the need for further reductive equivalents or electron …

It is a great challenge to optionally access diverse hydroxylation products from a given
substrate bearing multiple reaction sites of sp3 and sp2 C− H bonds. Herein, we report the …

Fungal unspecific peroxygenases (UPOs) represent an enzyme class catalysing versatile
oxyfunctionalisation reactions on a broad substrate scope. They are occurring as secreted …