Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …

Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than
40 million people worldwide and it is predicted to exponentially increase in the coming …

Autophagy is a highly coordinated process that is controlled at several levels including
transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear …

Neurofibrillary tangles and amyloid plaques constitute the hallmark brain lesions of
Alzheimer's disease (AD) patients. Tangles are composed of fibrillar aggregates of the …

Although historically perceived as a disorder confined to the brain, our understanding of
Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with …

Although great advances in elucidating the molecular basis and pathogenesis of
Alzheimer's disease (AD) have been made and multifarious novel therapeutic approaches …

The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …

Part of the inflammatory response in Alzheimer's disease (AD) is the upregulation of the
inducible nitric oxide synthase (NOS2) resulting in increased NO production. NO contributes …

The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …

Cytoskeletal abnormalities and synaptic loss, typical of both familial and sporadic Alzheimer
disease (AD), are induced by diverse stresses such as neuroinflammation, oxidative stress …