Murine models of psoriasis and their usefulness for drug discovery

SY Chuang, CH Lin, CT Sung… - Expert opinion on drug …, 2018 - Taylor & Francis
Introduction: Psoriasis is an autoimmune skin disease characterized by red plaques with
silver or white multilayered scales with a thickened acanthotic epidermis. Using mouse …

Frailty index as a biomarker of lifespan and healthspan: focus on pharmacological interventions

DL Palliyaguru, JM Moats, C Di Germanio… - Mechanisms of Ageing …, 2019 - Elsevier
Although survival has been the focus of aging research for many years, the field is rapidly
evolving towards incorporating healthspan and health indices in studies that explore aging …

Effective topical treatments using innovative NNO-tridentate vanadium (iv) complexes-mediated photodynamic therapy in a psoriasis-like mouse model

RK Lin, P Venkatesan, CH Yeh, CM Chien… - Journal of Materials …, 2022 - pubs.rsc.org
Psoriasis is a chronic inflammatory skin disease that can significantly impact the quality of
human life. Various drug treatments are available; however, due to their long-term severe …

[HTML][HTML] Protective effects of acarbose against insulitis in multiple low-dose streptozotocin-induced diabetic mice

B Zhao, F Wu, X Han, W Zhou, Q Shi, H Wang - Life Sciences, 2020 - Elsevier
Aims The development of type 1 diabetes is associated with inflammatory lesion of the
pancreatic islets, known as insulitis. In this study, we focused on the protective effects of …

Alpha-glucosidase inhibitors alter gut microbiota and ameliorate collagen-induced arthritis

L Zhang, P Song, X Zhang, C Metea… - Frontiers in …, 2020 - frontiersin.org
Acarose is an anti-diabetic drug and exhibits anti-arthritic effects. We hypothesized that
acarbose influences the gut microbiota to affect the course of arthritis and tested this …

Acarbose reduces Pseudomonas aeruginosa respiratory tract infection in type 2 diabetic mice

L Liu, H Fan, L Li, Y Fan - Respiratory Research, 2023 - Springer
Background Type 2 diabetes mellitus (T2DM) is widely prevalent worldwide, and respiratory
tract infections (RTIs) have become the primary cause of death for T2DM patients who …

[HTML][HTML] Salvianolic acid B ameliorates psoriatic changes in imiquimod-induced psoriasis on BALB/c mice by inhibiting inflammatory and keratin markers via altering …

S Wang, L Zhu, Y Xu, Z Qin… - The Korean journal of …, 2020 - synapse.koreamed.org
Salvianolic acid B (SAB) is an active phytocomponent of a popular Chinese herb called
Radix Salvia militiorrhiza with numerous biological properties. The anti-psoriasis activity of …

The direct and indirect inhibition of proinflammatory adipose tissue macrophages by acarbose in diet-induced obesity

X Li, S Zheng, H Xu, Z Zhang, X Han, Y Wei, H Jin… - Cell Reports …, 2025 - cell.com
Inflammation is critical for obesity and obesity-induced insulin resistance (IR). In this study,
we reveal the function and mechanism of acarbose on adipose tissue macrophage (ATM) …

The “entanglement” between bullous pemphigoid and diabetes mellitus: a comprehensive review and expert recommendations

JH Li, YG Zuo - Expert Review of Clinical Immunology, 2024 - Taylor & Francis
Introduction Bullous pemphigoid (BP) is an autoimmune bullous disease characterized by
subepidermal tense blisters, accompanied by urticarial or eczema-like lesions. Circulating …

Ginsenoside Rg1 abolish imiquimod‐induced psoriasis‐like dermatitis in BALB/c mice via downregulating NF‐κB signaling pathway

Q Shi, Q He, W Chen, J Long… - Journal of food …, 2019 - Wiley Online Library
This animal experiment was framed to evaluate the beneficial effect of ginsenoside Rg1
(GRg1) against imiquimod (IMQ)‐induced psoriasis‐like dermatitis model to reveal the …