Organophosphate pesticide exposure and neurodegeneration

F Sánchez-Santed, MT Colomina, EH Hernández - Cortex, 2016 - Elsevier
Organophosphate pesticides (OPs) are used extensively throughout the world. The main
sources of contamination for humans are dietary ingestion and occupational exposures. The …

Atypical aging in Down syndrome

WB Zigman - Developmental disabilities research reviews, 2013 - Wiley Online Library
At present, there may be over 210,000 people with Down syndrome (DS) over the age of 55
in the United States (US) who have significant needs for augmented services due to …

Alzheimer's disease in Down syndrome: neurobiology and risk

WB Zigman, IT Lott - Mental retardation and developmental …, 2007 - Wiley Online Library
Down syndrome (DS) is characterized by increased mortality rates, both during early and
later stages of life, and age‐specific mortality risk remains higher in adults with DS …

Gender differences in dementia risk factors

NA Azad, M Al Bugami, I Loy-English - Gender medicine, 2007 - Elsevier
Background: With the aging of the population, dementia has become an important health
concern in most countries. There is a growing body of literature on the importance of …

Cholesterol, APOE genotype, and Alzheimer disease: An epidemiologic study of Nigerian Yoruba

K Hall, J Murrell, A Ogunniyi, M Deeg, O Baiyewu… - Neurology, 2006 - AAN Enterprises
Objective: To examine the relationship between cholesterol and other lipids, APOE
genotype, and risk of Alzheimer disease (AD) in a population-based study of elderly Yoruba …

Alzheimer's disease in adults with Down syndrome

WB Zigman, DA Devenny, SJ Krinsky‐McHale… - International review of …, 2008 - Elsevier
Down syndrome is associated with increased mortality rates due to congenital cardiac
defects and leukemia early in life, and with Alzheimer's disease and a tendency toward …

Pharmacogenomics in Alzheimer's disease

R Cacabelos - … in Drug Discovery and Development: From Bench to …, 2008 - Springer
Pharmacological treatment in Alzheimer's disease (AD) accounts for 10–20% of direct costs,
and fewer than 20% of AD patients are moderate responders to conventional drugs …

Cardiovascular risk factors and cognitive function in adults 30–59 years of age (NHANES III)

VN Pavlik, DJ Hyman, R Doody - Neuroepidemiology, 2004 - karger.com
Abstract In the Third National Health and Nutrition Examination Survey (NHANES III), three
measures of cognitive function [Simple Reaction Time Test (SRTT), Symbol Digit …

Plasma high‐density lipoprotein cargo is altered in Alzheimer's disease and is associated with regional brain volume

S Pedrini, JD Doecke, E Hone, P Wang… - Journal of …, 2022 - Wiley Online Library
Cholesterol levels have been repeatedly linked to Alzheimer's Disease (AD), suggesting that
high levels could be detrimental, but this effect is likely attributed to Low‐Density Lipoprotein …

Genomics of Dementia: APOE‐ and CYP2D6‐Related Pharmacogenetics

R Cacabelos, R Martínez… - International Journal …, 2012 - Wiley Online Library
Dementia is a major problem of health in developed societies. Alzheimer's disease (AD),
vascular dementia, and mixed dementia account for over 90% of the most prevalent forms of …