Can natural polymers assist in delivering insulin orally?

M Nur, T Vasiljevic - International journal of biological macromolecules, 2017 - Elsevier
Diabetes mellitus is one of the most grave and lethal non communicable diseases. Insulin is
normally used to medicate diabetes. Due to bioavailability issues, the most regular route of …

Physicochemical properties and formation mechanism of whey protein isolate-sodium alginate complexes: Experimental and computational study

X Liu, X Qin, Y Wang, J Zhong - Food Hydrocolloids, 2022 - Elsevier
The study explored the interaction mechanism between whey protein isolate and
polysaccharide at the molecular level. Firstly, the effect of pH on the formation of whey …

[HTML][HTML] Complex coacervates of β-lactoglobulin/sodium alginate for the microencapsulation of black pepper (Piper nigrum L.) essential oil: Simulated gastrointestinal …

LPH Bastos, B de Sá Costa, RP Siqueira… - International Journal of …, 2020 - Elsevier
This study evaluated the most appropriate conditions (pH and biopolymers ratio) for the
formation of the complex between β-lactoglobulin (β-lg) and sodium alginate (NaAlg) …

Impact of alginate mannuronic-guluronic acid contents and pH on protein binding capacity and complex size

M Madsen, P Westh, S Khan, R Ipsen… - …, 2021 - ACS Publications
Alginates, serving as hydrocolloids in the food and pharma industries, form particles at pH<
4.5 with positively charged proteins, such as β-lactoglobulin (β-Lg). Alginates are linear …

Vitamin D3 cress seed mucilage-β-lactoglobulin nanocomplexes: Synthesis, characterization, encapsulation and simulated intestinal fluid in vitro release

A Taheri, M Kashaninejad, AM Tamaddon… - Carbohydrate …, 2021 - Elsevier
Abstract Vitamin D 3 (VD 3) as an essential lipid-soluble active ingredient with numerous
applications in food and pharmaceutical sectors; however, poor water solubility reduces its …

Tuning alginate β-lactoglobulin complex coacervation by modulating pH and temperature

M Madsen, H Mohammad-Beigi, P Westh… - Soft Matter, 2023 - pubs.rsc.org
The use of biomolecules in food matrices and encapsulation systems is, as in other areas,
moving towards greener solutions and a center piece here is the complex coacervation …

The effect of protein-to-alginate ratio on in vitro gastric digestion of nanoparticulated whey protein

G Koutina, CA Ray, R Lametsch, R Ipsen - International dairy journal, 2018 - Elsevier
The in vitro digestion of particles composed of nanoparticulated whey protein (unheated and
heated for 85° C for 10 min) and two types of alginate [low (40 kDa) and high (280 kDa) …

Tragacanth as an oral peptide and protein delivery carrier: Characterization and mucoadhesion

M Nur, L Ramchandran, T Vasiljevic - Carbohydrate polymers, 2016 - Elsevier
Biopolymers such as tragacanth, an anionic polysaccharide gum, can be alternative
polymeric carrier for physiologically important peptides and proteins. Characterization of …

Effect of alginate size, mannuronic/guluronic acid content and pH on particle size, thermodynamics and composition of complexes with β-lactoglobulin

EGP Stender, S Khan, R Ipsen, F Madsen… - Food …, 2018 - Elsevier
Alginate is an anionic polysaccharide capable of forming insoluble particles with proteins.
Hence, alginate has potential as a protein carrier. However, the role of physical properties of …

Insulin inclusion into a tragacanth hydrogel: An oral delivery system for insulin

M Nur, T Vasiljevic - Materials, 2018 - mdpi.com
Nanoparticles or microparticles created by physical complexation between two
polyelectrolytes may have a prospective use as an excipient for oral insulin administration …