Gene transfer is a potentially powerful tool for the treatment of a wide variety of diseases.
The transfer of these genes is achleved by utilizing a variety of vectors, including retroviral …

We established an orthotopic animal model of colon cancer in mice and applied this model
to study the antitumor effects of B7–H3, the newest member of the B7 family of costimulatory …

Many technical difficulties have to be overcome before effective gene therapy can be
achieved. Strategies for gene therapy include'suicide'gene therapy, transfer of a tumor …

We have previously demonstrated that intratumoral injection with Ad vectors expressing IL-2
or IL-12 can induce regression in a murine breast cancer model. These IL-2-or IL-12 …

Tumors that express tumor-specific antigens can maintain growth in an immunocompetent
organism. Current hypotheses tend toward T cell anergy as a key component for the …

Previously, we showed that expression of B7–1 in CMT93 murine colorectal tumour cells
inhibited their growth in immunocompetent animals. However, this did not result in any …

To develop immunogene therapy targeting minimal residual hematopoietic tumor cells in
patients, we transduced murine GM-CSF or CD80 gene into murine WEHI 3B …

Publisher Summary Cytokines include heterogeneous groups of glycoproteins that act
locally in minute concentrations to mediate intercellular relationships by either activating or …

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is a highly
aggressive malignancy caused by the bcr-abl translocation oncogene. To explore …

The majority of tumour cells do not express immune costimulatory molecules and this may
account for their inability to stimulate directly an antitumour T cell response. Here we report …