Locomotion results from intricate dynamic interactions between a central program and
feedback mechanisms. The central program relies fundamentally on a genetically …

Movement is accomplished by the controlled activation of motor unit populations. Our
understanding of motor unit physiology has been derived from experimental work on the …

The dendrites of motoneurons are not, as once thought, passive conduits for synaptic inputs.
Instead they have voltage‐dependent channels that provide the capacity to generate a very …

Serotonin (5-hydroxytryptamine, 5-HT), the “happy hormone,” has a phylogenetically ancient
role in neural transmission (Turlejski, 1996). Because the serotonergic system has a …

A commonly observed neural correlate of working memory is firing that persists after the
triggering stimulus disappears. Substantial effort has been devoted to understanding the …

Persistent neural activity refers to a sustained change in action potential discharge that long
outlasts a stimulus. It is found in a diverse set of brain regions and organisms and several in …

Motor fatigue induced by physical activity is an everyday experience characterized by a
decreased capacity to generate motor force. Factors in both muscles and the central nervous …

We studied wild-type (WT) and Cav1. 3−/− mouse chromaffin cells (MCCs) with the aim to
determine the isoform of L-type Ca2+ channel (LTCC) and BK channels that underlie the …

Injury to the nerve can produce changes in dorsal horn function and pain. This facilitated
processing may be mediated in part by voltage-sensitive calcium channels. Activation of …

In the months after spinal cord transection, motoneurons in the rat spinal cord develop large
persistent inward currents (PICs) that are responsible for muscle spasticity. These PICs are …