Lytic enzymes encoded by bacteriophages have been intensively explored as alternative
agents for combating bacterial pathogens in different contexts. The antibacterial character of …

Appearance of pathogenic bacteria resistant to most, if not all, known antibiotics is currently
one of the most significant medical problems. Therefore, development of novel antibacterial …

Mycobacterial infections are considered to a serious challenge of medicine, and the
emergence of MDR and XDR tuberculosis is a serious public health problem. Tuberculosis …

Pseudomonas aeruginosa is an important pathogen that causes serious infections. Bacterial
biofilms are highly resistant and render bacterial treatment very difficult, therefore …

Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tuberculosis) is a highly
infectious disease and worldwide health problem. Based on the WHO TB report, 9 million …

The emergence of antibiotic resistance in Mycobacterium tuberculosis has been the culprit
behind the inefficient treatment of tuberculosis (TB). Mycobacteriophages being rapid and …

D29 mycobacteriophage encodes LysA endolysin, which mediates mycobacterial host cell
lysis by targeting its peptidoglycan layer, thus projecting itself as a potential therapeutic …

Mycobacteriophages are viruses that specifically infect mycobacteria, which ultimately
culminate in host cell death. Dedicated enzymes targeting the complex mycobacterial cell …

The glycoside hydrolase 19 (GH19) is a bifunctional family of chitinases and endolysins,
which have been studied for the control of plant fungal pests, the recycle of chitin biomass …

Endolysins produced by bacteriophages hydrolyze host cell wall peptidoglycan to release
newly assembled virions. D29 mycobacteriophage specifically infects mycobacteria …