Reviewing the potential of psychedelics for the treatment of PTSD
E Krediet, T Bostoen, J Breeksema… - International Journal …, 2020 - academic.oup.com
There are few medications with demonstrated efficacy for the treatment of posttraumatic
stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy …
stress disorder (PTSD). Treatment guidelines have unequivocally designated psychotherapy …
A network-based neurobiological model of PTSD: evidence from structural and functional neuroimaging studies
Abstract Purpose of Review Although a fine-grained understanding of the neurobiology of
posttraumatic stress disorder (PTSD) is yet to be elucidated, the last two decades have seen …
posttraumatic stress disorder (PTSD) is yet to be elucidated, the last two decades have seen …
A randomized controlled trial of repeated ketamine administration for chronic posttraumatic stress disorder
Objective: Posttraumatic stress disorder (PTSD) is a chronic and disabling disorder, for
which available pharmacotherapies have limited efficacy. The authors' previous proof-of …
which available pharmacotherapies have limited efficacy. The authors' previous proof-of …
Lower synaptic density is associated with depression severity and network alterations
SE Holmes, D Scheinost, SJ Finnema… - Nature …, 2019 - nature.com
Synaptic loss and deficits in functional connectivity are hypothesized to contribute to
symptoms associated with major depressive disorder (MDD) and post-traumatic stress …
symptoms associated with major depressive disorder (MDD) and post-traumatic stress …
The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?
The discovery of the antidepressant effects of ketamine has opened a breakthrough
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
Chronic stress weakens connectivity in the prefrontal cortex: architectural and molecular changes
E Woo, LH Sansing, AFT Arnsten, D Datta - Chronic Stress, 2021 - journals.sagepub.com
Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …
The neurobiology and pharmacotherapy of posttraumatic stress disorder
New approaches to the neurobiology of posttraumatic stress disorder (PTSD) are needed to
address the reported crisis in PTSD drug development. These new approaches may require …
address the reported crisis in PTSD drug development. These new approaches may require …
PTSD as a public mental health priority
P Watson - Current psychiatry reports, 2019 - Springer
Abstract Purpose of Review This article reviews recent evidence related to public health
epidemiology and intervention for traumatic stress and PTSD. Recent evidence is presented …
epidemiology and intervention for traumatic stress and PTSD. Recent evidence is presented …
Diverse therapeutic developments for post-traumatic stress disorder (PTSD) indicate common mechanisms of memory modulation
Post-traumatic stress disorder (PTSD), characterized by abnormally persistent and
distressing memories, is a chronic debilitating condition in need of new treatment options …
distressing memories, is a chronic debilitating condition in need of new treatment options …
Imaging the effect of ketamine on synaptic density (SV2A) in the living brain
SE Holmes, SJ Finnema, M Naganawa… - Molecular …, 2022 - nature.com
The discovery of ketamine as a rapid and robust antidepressant marks the beginning of a
new era in the treatment of psychiatric disorders. Ketamine is thought to produce rapid and …
new era in the treatment of psychiatric disorders. Ketamine is thought to produce rapid and …