Chikungunya fever: epidemiology, clinical syndrome, pathogenesis and therapy
SD Thiberville, N Moyen, L Dupuis-Maguiraga… - Antiviral research, 2013 - Elsevier
Chikungunya virus (CHIKV) is the aetiological agent of the mosquito-borne disease
chikungunya fever, a debilitating arthritic disease that, during the past 7 years, has caused …
chikungunya fever, a debilitating arthritic disease that, during the past 7 years, has caused …
Direct inhibition of IRF-dependent transcriptional regulatory mechanisms associated with disease
A Antonczyk, B Krist, M Sajek, A Michalska… - Frontiers in …, 2019 - frontiersin.org
Interferon regulatory factors (IRFs) are a family of homologous proteins that regulate the
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …
transcription of interferons (IFNs) and IFN-induced gene expression. As such they are …
IRF-3, IRF-5, and IRF-7 coordinately regulate the type I IFN response in myeloid dendritic cells downstream of MAVS signaling
Although the transcription factors IRF-3 and IRF-7 are considered master regulators of type I
interferon (IFN) induction and IFN stimulated gene (ISG) expression, Irf3−/−× Irf7−/− double …
interferon (IFN) induction and IFN stimulated gene (ISG) expression, Irf3−/−× Irf7−/− double …
Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus
P Pal, KA Dowd, JD Brien, MA Edeling… - PLoS …, 2013 - journals.plos.org
Chikungunya virus (CHIKV) is a mosquito-transmitted alphavirus that causes global
epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the …
epidemics of a debilitating polyarthritis in humans. As there is a pressing need for the …
MAVS signaling is required for preventing persistent chikungunya heart infection and chronic vascular tissue inflammation
Chikungunya virus (CHIKV) infection has been associated with severe cardiac
manifestations, yet, how CHIKV infection leads to heart disease remains unknown. Here, we …
manifestations, yet, how CHIKV infection leads to heart disease remains unknown. Here, we …
Chikungunya virus: pathophysiology, mechanism, and modeling
VK Ganesan, B Duan, SP Reid - Viruses, 2017 - mdpi.com
Chikungunya virus (CHIKV), a mosquito-transmitted alphavirus, is recurring in epidemic
waves. In the past decade and a half, the disease has resurged in several countries around …
waves. In the past decade and a half, the disease has resurged in several countries around …
Viperin restricts chikungunya virus replication and pathology
TS Teng, SS Foo, D Simamarta… - The Journal of …, 2012 - Am Soc Clin Investig
Chikungunya virus (CHIKV) is a mosquito-borne arthralgia arbovirus that is reemergent in
sub-Saharan Africa and Southeast Asia. CHIKV infection has been shown to be self-limiting …
sub-Saharan Africa and Southeast Asia. CHIKV infection has been shown to be self-limiting …
Interferon response factors 3 and 7 protect against Chikungunya virus hemorrhagic fever and shock
Chikungunya virus (CHIKV) infections can produce severe disease and mortality. Here we
show that CHIKV infection of adult mice deficient in interferon response factors 3 and 7 …
show that CHIKV infection of adult mice deficient in interferon response factors 3 and 7 …
Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish
Chikungunya Virus (CHIKV), a re-emerging arbovirus that may cause severe disease,
constitutes an important public health problem. Herein we describe a novel CHIKV infection …
constitutes an important public health problem. Herein we describe a novel CHIKV infection …
Chikungunya virus pathogenesis: From bedside to bench
T Couderc, M Lecuit - Antiviral research, 2015 - Elsevier
Chikungunya virus (CHIKV) is an arbovirus transmitted to humans by mosquito bite. A
decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then …
decade ago, the virus caused a major outbreak in the islands of the Indian Ocean, then …