Recent advances in structural biology and computational techniques have revealed
allosteric mechanisms for an abundance of targets leading to the establishment of rational …

Highlights•Residue interaction networks provide a graph-based description of protein
structure.•RINs provide a computationally effective way to obtain important topological …

Allosteric regulation is the most direct and efficient way of regulating protein function,
wherein proteins transmit the perturbations at one site to another distinct functional site …

Allosteric regulation plays a central role in orchestrating diverse cellular processes. A
prerequisite for allostery is a flexible biomolecule within which two distal sites can …

Cystic fibrosis (CF) is a recessive genetic disease that is caused by mutations in the cystic
fibrosis transmembrane conductance regulator (CFTR) protein. The recent development of a …

Transcription factor IIH (TFIIH) is a protein assembly essential for transcription initiation and
nucleotide excision repair (NER). Yet, understanding of the conformational switching …

Simulation datasets of proteins (eg, those generated by molecular dynamics simulations)
are filled with information about how a non-covalent interaction network within a protein …

Network analysis has emerged as a powerful tool for examining structural biology systems.
The spatial organization of the components of a biomolecular structure has been rendered …

Describing protein dynamical networks through amino acid contacts is a powerful way to
analyze complex biomolecular systems. However, due to the size of the systems, identifying …

Transcription-coupled repair is essential for the removal of DNA lesions from the transcribed
genome. The pathway is initiated by CSB protein binding to stalled RNA polymerase II …