The aging of population has become an issue of great concern because of its rapid
increase. Aging is an important risk factor of many chronic diseases. Resveratrol could be …

Resveratrol is a pleiotropic phytochemical belonging to the stilbene family. Though it is only
significantly present in grape products, a huge amount of preclinical studies investigated its …

Doxorubicin‐(DOX‐) induced cardiotoxicity is associated with oxidative stress and
cardiomyocyte apoptosis. The adaptor protein p66Shc regulates the cellular redox status …

Background The activation of NAD+-dependent deacetylase, Sirt1, by the administration of
nicotinamide mononucleotide (NMN) ameliorates various aging-related diseases. Methods …

The mechanisms leading to neuronal death in Parkinson's disease (PD) are not fully
elucidated; however, mounting evidence implicates endoplasmic reticulum (ER) stress …

Simple Summary In addition to cancer-related factors, anti-cancer chemotherapy treatment
can drive life-threatening body wasting in a syndrome known as cachexia. Emerging …

Breast cancer is the most common malignancy in women of the Western world. Doxorubicin
(DOX) continues to be used extensively to treat early-stage or node-positive breast cancer …

The hormone erythropoietin (EPO) has been demonstrated to protect against chemotherapy
drug doxorubicin (DOX)-induced cardiotoxicity, but the underlying mechanism remains …

The prevalence of neurodegenerative disorders characterized by the loss of neuronal
function is rapidly increasing. The pathogenesis of the majority of these diseases is not …

Abstract Epigallocatechin-3-gallate (EGCG), a major polyphenol component of green tea,
presents anticancer efficacy. However, its exact mechanism of action is not known. In this …