Stem cells can self-renew and produce different cell types, thus providing new strategies to
regenerate missing tissues and treat diseases. In the field of dentistry, adult mesenchymal …

The mammalian salivary gland develops as a highly branched structure designed to
produce and secrete saliva. This review will focus on research on mouse submandibular …

Current saliva-based stimulation therapies for radiotherapy-induced xerostomia are not fully
effective due to the presence of damaged secretory epithelia and nerves in the salivary …

Salivary gland (SG) dysfunction impairs the life quality of many patients, such as patients
with radiation therapy for head and neck cancer and patients with Sjögren's syndrome …

Salivary glands are formed by branching morphogenesis with epithelial progenitors forming
a network of ducts and acini (secretory cells). During this process, epithelial progenitors …

Acinar cells play an essential role in the secretory function of exocrine organs. Despite this
requirement, how acinar cells are generated during organogenesis is unclear. Using the …

Organ formation and regeneration require epithelial progenitor expansion to engineer,
maintain, and repair the branched tissue architecture. Identifying the mechanisms that …

Stem cell–based regenerative therapy is a promising treatment for head and neck cancer
patients that suffer from chronic dry mouth (xerostomia) due to salivary gland injury from …

Dental pulp stem cells, or DPSC, are neural crest-derived cells with an outstanding capacity
to differentiate along multiple cell lineages of interest for cell therapy. In particular, highly …

Salivary glands are responsible for maintaining the health of the oral cavity and are routinely
damaged by therapeutic radiation for head and neck cancer as well as by autoimmune …