The oral mucosal barrier is constantly exposed to a plethora of triggers requiring immune
control, including a diverse commensal microbiome, ongoing damage from mastication, and …

In their classic 1976 paper, Page & Schroeder described the histopathologic events and the
types of myeloid cells and lymphocytes involved in the initiation and progression of …

Alveolar bone is a unique osseous tissue due to the proximity of dental plaque biofilms.
Periodontal health and homeostasis are mediated by a balanced host immune response to …

Guided bone regeneration (GBR) is a widely used technique in preclinical and clinical
studies due to its predictability. Its main purpose is to prevent the migration of soft tissue into …

Aim Osteoimmunology covers the cellular and molecular mechanisms responsible for
inflammatory osteolysis that culminates in the degradation of alveolar bone …

Periodontal disease is characterised by a dense inflammatory infiltrate in the connective
tissue. When the resolution is not achieved, the activation of T and B cells is crucial in …

The oral cavity is inhabited by a wide spectrum of microbial species, and their colonization is
mostly based on commensalism. These microbes are part of the normal oral flora, but there …

Human oral soft tissues provide the first barrier of defence against chronic inflammatory
disease and hold a remarkable scarless wounding phenotype. Tissue homeostasis requires …

B cells play a vital role in the elimination of periodontal pathogens, the regulation of the
immune response, and the induction of tissue destruction. However, the role of B cells in the …

Bone infection and inflammation leads to the infiltration of immune cells at the site of
infection, where they modulate the differentiation and function of osteoclasts and osteoblasts …