Diffusion-weighted magnetic resonance imaging (DWI) is a non-invasive method sensitive to
local water motion in the tissue. As a tool to probe the microstructure, including the presence …

Biomaterials developed to treat bone defects have classically focused on bone healing via
direct, intramembranous ossification. In contrast, most bones in our body develop from a …

It is well-known that collagen is the most abundant protein in the human body; however,
what is not often appreciated is its fascinating physical chemistry and molecular physics. In …

Electrical signals are present in the extracellular spaces between neural cells. To mimic the
electrophysiological environment for peripheral nerve regeneration, this study was intended …

Magnetic resonance transverse spin relaxation time constants (T 2) of water protons in
ordered collagenous tissues are dependent on the orientation of the tissue relative to the …

In vivo, eukaryotic cells are embedded in a matrix environment, where they grow and
develop. Generally, this extracellular matrix (ECM) is an anisotropic fibrous structure …

Collagen fibre architecture in articular cartilage is commonly described in terms of the
predominant direction of fibre alignment. X-ray scattering has been used to study the …

Noninvasive methods to detect microstructural changes in collagen-based fibrous tissues
are necessary to differentiate healthy from damaged tissues in vivo but are sparse. Diffusion …

Complex materials are ubiquitous in science, engineering and nature. One important
parameter for characterising their morphology is the degree of anisotropy. Magnetic …

Measurements of the orientational dispersion of collagen fibers in articular cartilage were
made using diffusion tensor imaging (DTI) and small-angle X-ray scattering (SAXS) on …