The heart has a high rate of ATP production and turnover that is required to maintain its
continuous mechanical work. Perturbations in ATP-generating processes may therefore …

Cardiovascular disease is the leading cause of death in western countries. Among
cardiovascular diseases, myocardial infarction represents a life-threatening condition …

Adipocytes undergo intense energetic stress in obesity resulting in loss of mitochondrial
mass and function. We have found that adipocytes respond to mitochondrial stress by …

The obesity epidemic has led to an increased incidence of nonalcoholic fatty liver disease
(NAFLD) and type 2 diabetes. AMP-activated protein kinase (Ampk) regulates energy …

The neonatal mammalian heart is capable of regeneration for a brief window of time after
birth. However, this regenerative capacity is lost within the first week of life, which coincides …

Heart disease is a leading cause of death worldwide. In many forms of heart disease,
including heart failure, ischaemic heart disease and diabetic cardiomyopathies, changes in …

Emerging evidence supports that cancer incidence is increased in patients with
cardiovascular (CV) disease and heart failure (HF), and patients with HF frequently die from …

Reducing infarct size during a cardiac ischaemic‐reperfusion episode is still of paramount
importance, because the extension of myocardial necrosis is an important risk factor for …

Background—Cardiac hypertrophy is accompanied by significant alterations in energy
metabolism. Whether these changes in energy metabolism precede and contribute to the …

Rationale: Myocardial vulnerability to ischemia/reperfusion (I/R) injury is strictly regulated by
energy substrate metabolism. Branched chain amino acids (BCAA), consisting of valine …