Glycine receptors (GlyR) are inhibitory Cys-loop ion channels that contribute to the control of
excitability along the central nervous system (CNS). GlyR are found in the spinal cord and …

Background: Traditional drug discovery is a lengthy process which involves a huge amount
of resources. Modern-day drug discovers various multidisciplinary approaches amongst …

Antagonism of ionotropic GABA receptors (iGABARs) can occur at three distinct types of
receptor binding sites causing chemically induced epileptic seizures. Here we review three …

Abstract Ethnopharmacological relevance Ferula gummosa Boiss., known in Persian as
“Baridje,” belongs to the Apiaceae family. All parts of this plant, especially the root, contain …

The pentameric γ-aminobutyric acid type A receptors are ion channels activated by ligands,
which intervene in the rapid inhibitory transmission in the mammalian CNS. Due to their rich …

The RDL receptor is one of the most relevant protein targets for insecticide molecules. It
belongs to the pentameric ligand-gated ion channel (pLGIC) family. Given that the …

Biological cell is the fundamental building block of every living system. The plasma
membrane, a phospholipid bilayer consisting of two asymmetric leaflets, defines its …

GABAA receptors (GABAARs) are crucial in mediating inhibition in the adult mammalian
brain. Although the kinetics of this receptor has been extensively studied, the molecular …

The γ-amino butyric acid type A receptors (GABAA-Rs) are the key players in the
mammalian brain that meditate fast inhibitory neurotransmission events. The structural …

Uridine 5′-diphospho-glucuronosyltransferase-1A9 (UGT1A9) expressed in the liver,
shows good sequence identity with UGT1A10, expressed in the intestine. Both uridine 5 …