Brain derived neurotrophic factor (BDNF), a member of the neurotrophin family of structurally
related proteins that promote neuronal differentiation and survival during development [1, 2] …

Drugs of abuse produce widespread effects on the structure and function of neurons
throughout the brain's reward circuitry, and these changes are believed to underlie the long …

The effects of brain-derived neurotrophic factor (BDNF) on cocaine-seeking are brain region-
specific. Infusion of BDNF into subcortical structures, like the nucleus accumbens and …

Background Sleep plays a pivotal role in normal biological functions. Sleep loss results in
higher stress vulnerability and is often found in mental disorders. There is evidence that …

Genetic and environmental factors play a role in the development of alcoholism. Whole-
genome expression profiling has highlighted the importance of several genes that may …

Background: The purpose of this study was to examine relationships between genetic
markers of central serotonin (5‐HT) and dopamine function, and risk for post‐treatment …

BACKGROUND: Increased susceptibility for developing alcohol dependence (AD) might be
related to structural differences in brain circuits that influence the salience of rewards and/or …

Alcohol use disorders (AUDs) are complex and developing effective treatments will require
the combination of novel medications and cognitive behavioral therapy approaches …

BACKGROUND: Ventral tegmental area (VTA) brain-derived neurotrophic factor (BDNF)
contributes to time-dependent increases in cue-induced cocaine seeking after withdrawal …

Abstract Development of effective treatments for alcohol use disorder (AUD) represents an
important public health goal. This review provides a summary of completed preclinical and …