Cancer chemoresistance is a problematic dilemma that significantly restrains numerous
cancer management protocols. It can promote cancer recurrence, spreading of cancer, and …

Sphingolipids, crucial components of cellular membranes, play a vital role in maintaining
cellular structure and signaling integrity. Disruptions in sphingolipid metabolism are …

Transporting small molecules across cell membranes is an essential process in cell
physiology. Many structurally diverse, secondary active transporters harness …

One hundred and fifty years ago, Johann Thudichum described sphingolipids as unusual
“Sphinx-like” lipids from the brain. Today, we know that thousands of sphingolipid molecules …

Abstract The LAT1-4F2hc complex (SLC7A5-SLC3A2) facilitates uptake of essential amino
acids, hormones and drugs. Its dysfunction is associated with many cancers and …

The mammalian membrane is composed of various eukaryotic lipids interacting with
extensively post-translationally modified proteins. Probing interactions between these …

About one in 500 children is born with significant hearing impairment, and at least half of the
cases have genetic causes (1). Two-or threefold more children have normal hearing at birth …

Capturing the dynamics of G-protein-coupled receptors (GPCRs) as they transduce
extracellular signals into key physiological processes remains one of the most challenging …

Abstract Sphingosine-1-phosphate (S1P) is a signaling lysolipid critical to heart
development, immunity, and hearing. Accordingly, mutations in the S1P transporter SPNS2 …

The proto-oncogenic PI3K pathway is crucial for the integration of growth factor signaling
and metabolic pathways to facilitate the coordination for cell growth. Since transformed cells …