Cerebral malaria is the most severe neurological complication of Plasmodium falciparum
malaria. Even though this type of malaria is most common in children living in sub-Saharan …

Despite considerable efforts, malaria is still one of the most devastating infectious diseases
in the tropics. The rapid spread of antimalarial drug resistance currently compounds this …

Background Between 1995 and 2000, KwaZulu–Natal province, South Africa, experienced a
marked increase in Plasmodium falciparum malaria, fuelled by pyrethroid and sulfadoxine …

Antimalarial drug efficacy in uncomplicated malaria should be assessed parasitologically in
large, community-based trials, enrolling the age groups most affected by clinical disease …

Artemisinin combination therapies (ACTs) have recently been adopted as first-line therapy
for Plasmodium falciparum infections in most malaria-endemic countries. In this study, we …

The practical advantages of sampling and storing blood on filter paper for analyses of
human and pathogen genes highlight the need for reliable, sensitive, and cost-effective DNA …

The choice of partner drug is critical for artemisinine-based combination therapy (ACT) to
remain effective and amodiaquine (AQ) is one important candidate to evaluate. We treated …

Background. This is the first clinical trial comparing the efficacy of artesunate plus
amodiaquine (ASAQ) and artemether-lumefantrine (AL)—the major artemisinin-based …

The persistence of parasite histidine-rich protein 2 (HRP2) in the circulation after parasite
clearance has been considered a drawback for rapid diagnostic tests (RDTs) targeting …

Genotyping frequently is used to distinguish recrudescent from new infections in antimalarial
drug efficacy trials, but methodology and interpretation of results have not been …