Traditionally, lymphocytic interferon γ (IFN-γ) was considered to be a simple'booster'of
proinflammatory responses by microglia (brain-resident macrophages) during bacterial or …

The predominant type of immune cell in the brain is the microglia, a type of tissue-resident
macrophage. In a variety of neurodegenerative settings, microglia alter their transcriptional …

Early-life inflammation increases the risk for depression in later life. Here, we demonstrate
how early-life inflammation causes adolescent depressive-like symptoms: by altering the …

Recent findings in human samples and animal models support the involvement of
inflammation in the development of Parkinson's disease. Nevertheless, it is currently …

Alzheimer's disease (AD) is characterized by beta-amyloid accumulation, phosphorylated
tau formation, hyperactivation of glial cells, and neuronal loss. The mechanisms of AD …

CD68 is a heavily glycosylated glycoprotein that is highly expressed in macrophages and
other mononuclear phagocytes. Traditionally, CD68 is exploited as a valuable cytochemical …

Scavenger receptors belong to a superfamily of proteins that are structurally heterogeneous
and encompass the miscellaneous group of transmembrane proteins and soluble secretory …

Background Interactions between neurons, astrocytes, and microglia critically influence
neuroinflammatory responses to insult in the central nervous system. In vitro astrocyte and …

Neuroinflammation driven by interferon‐gamma (IFN‐γ) and microglial activation has been
linked to neurological disease. However, the effects of IFN‐γ‐activated microglia on …

Infiltrating monocyte-derived macrophages (MDMs) and resident microglia dominate central
nervous system (CNS) injury sites. Differential roles for these cell populations after injury are …