Protein structure underlies essential biological processes and provides a blueprint for
molecular mimicry that drives drug discovery. Although small molecules represent the lion's …

Alkylations of chiral or achiral Ni (II) complexes of glycine Schiff bases constitute a landmark
in the development of practical methodology for asymmetric synthesis of α-amino acids …

This protocol provides a detailed procedure for the preparation of stapled α-helical peptides,
which have proven their potential as useful molecular probes and as next-generation …

The interaction between β-catenin and B-cell CLL/lymphoma 9 (BCL9), critical for the
transcriptional activity of β-catenin, is mediated by a helical segment from BCL9 and a large …

This review provides a comprehensive treatment of literature data dealing with asymmetric
synthesis of α-amino-β-hydroxy and α, β-diamino acids via homologation of chiral Ni (II) …

Chiral amino acids (AAs), being the main “building” blocks of the living organisms, are also
an important class of organic compounds which broadly applied in synthetic chemistry …

The major goal of this review is a critical discussion of the literature data on asymmetric
synthesis of α-amino acids via Michael addition reactions involving Ni (II)-complexes of …

Bicyclic peptides are promising scaffolds for the development of inhibitors of biological
targets that proved intractable by typical small molecules. So far, access to bioactive bicyclic …

Abstract Development of synthetic methodology for preparation of enantiomerically pure
fluorine containing amino acids (FAAs) is one of the most actively pursued areas of …

Tryptophan and its metabolites are involved in different physiological and
pathophysiological processes. Consequently, positron emission tomography (PET) tracers …