RONS and oxidative stress: An overview of basic concepts

AK Aranda-Rivera, A Cruz-Gregorio… - Oxygen, 2022 - mdpi.com
Oxidative stress (OS) has greatly interested the research community in understanding
damaging processes occurring in cells. OS is triggered by an imbalance between reactive …

Review on bee products as potential protective and therapeutic agents in male reproductive impairment

JB Suleiman, ABA Bakar, M Mohamed - Molecules, 2021 - mdpi.com
Bee products are sources of functional food that have been used in complementary
medicine to treat a variety of acute and chronic illnesses in many parts of the world. The …

Reproductive effects of subchronic exposure to acetamiprid in male rats

EY Arıcan, D Gökçeoğlu Kayalı, B Ulus Karaca… - Scientific reports, 2020 - nature.com
Acetamiprid, a selective agonist of nicotinic acetylcholine recetors, is one of the most widely
used neonicotinoids. There is limited data about toxicity of acetamiprid on male reproductive …

Regulation of Keap-1/Nrf2/AKT and iNOS/NF-κB/TLR4 signals by apocynin abrogated methotrexate-induced testicular toxicity: Mechanistic insights and computational …

AM Sayed, EHM Hassanein, FEM Ali, ZMM Omar… - Life sciences, 2021 - Elsevier
Aim Male reproductive toxicity is becoming of growing significance due to clinical
chemotherapy usage. Methotrexate (MTX) is an anti-folate used on a large scale for different …

[HTML][HTML] Fenofibrate and Diosmetin in a rat model of testicular toxicity: New insight on their protective mechanism through PPAR-α/NRF-2/HO-1 signaling pathway

MJ Alqahtani, WA Negm, HM Saad, EA Salem… - Biomedicine & …, 2023 - Elsevier
One of the most significant chemotherapeutic side effects of cisplatin (Cis) that limits its use
and efficacy is testicular toxicity. Thus, the objective of the present study was to investigate …

Combined apocynin and carvedilol protect against cadmium-induced testicular damage via modulation of inflammatory response and redox-sensitive pathways

AG Bakr, EHM Hassanein, FEM Ali, EAM El-Shoura - Life Sciences, 2022 - Elsevier
Testicular damage is considered a severe complication of cadmium (Cd) exposure which is
associated with tissue oxidative stress damage, inflammation, and apoptosis. The present …

Acetovanillone augmented the cardioprotective effect of carvedilol against cadmium-induced heart injury via suppression of oxidative stress and inflammation …

EHM Hassanein, AG Bakr, EAM El-Shoura… - Scientific reports, 2023 - nature.com
Cardiac toxicity is a public health issue that can be caused by both environmental and
occupational exposures. The current study aimed to investigate the effectiveness of …

Acetovanillone prevents cyclophosphamide‐induced acute lung injury by modulating PI3K/Akt/mTOR and Nrf2 signaling in rats

OAM Abd El‐Ghafar, EHM Hassanein… - Phytotherapy …, 2021 - Wiley Online Library
Cyclophosphamide (CP) is a medication used as an anticancer drug and to suppress the
immune system. However, its clinical applications are restricted because of the toxic and …

Apocynin and its chitosan nanoparticles attenuated cisplatin-induced multiorgan failure: Synthesis, characterization, and biological evaluation

NA Mahmoud, EHM Hassanein, EA Bakhite… - Life Sciences, 2023 - Elsevier
Cisplatin (CDDP) is an effective chemotherapeutic drug that has been used successfully in
treating various tumors. Although its higher antineoplastic agent activity, CDDP exhibited …

Trans-ferulic acid ameliorates cisplatin-induced testicular damage via suppression of TLR4, P38-MAPK, and ERK1/2 signaling pathways

EHM Hassanein, BA Abdel-Wahab, FEM Ali… - … Science and Pollution …, 2021 - Springer
Testicular damage has been described as a common side effect of cisplatin (CDDP), which
limits its clinical uses. Since oxidative injury and inflammatory response are the most …