The prevalence of obesity has tripled over the past four decades, imposing an enormous
burden on people's health. Polygenic (or common) obesity and rare, severe, early-onset …

Background Over the past 20 years, insights from human and mouse genetics have
illuminated the central role of the brain leptin-melanocortin pathway in the control of …

Genetic predisposition to obesity presents a paradox: how do genetic variants with a
detrimental impact on human health persist through evolutionary time? Numerous …

Obesity is a complex, heritable trait influenced by the interplay of genetics, epigenetics,
metagenomics and the environment. With the increasing access to high precision diagnostic …

Considerable attention has focused on deciphering the hypothalamic pathways that mediate
the behavioral and metabolic effects of leptin. We and others have identified several single …

Obesity and colorectal cancer (CRC) are among the leading diseases causing deaths in the
world, showing a complex multifactorial pathology. Obesity is considered a risk factor in …

Study of monogenic forms of obesity has demonstrated the pivotal role of the central leptin–
melanocortin pathway in controlling energy balance, appetite and body weight. The majority …

This narrative review aims to pinpoint mental and behavioral effects of starvation, which may
be triggered by hypoleptinemia and as such may be amenable to treatment with leptin …

Obesity rates have escalated to the point of a global pandemic with varying prevalence
across ethnic groups. These differences are partially explained by lifestyle factors in addition …

Pathogenic mutations in the appetite-regulating melanocortin-4 receptor (MC4R) represent
the most common cause of monogenic obesity with limited treatment options. Glucagon-like …