The cytochrome P450 (CYP) enzyme family is the most important enzyme system catalyzing
the phase 1 metabolism of pharmaceuticals and other xenobiotics such as herbal remedies …

Safe and effective use of drugs requires an understanding of metabolism and transport. We
identified the 100 most prescribed drugs in six countries and conducted a literature search …

Primary human hepatocytes (PHHs) have been the gold standard in vitro model for the
human liver and are crucial to predict hepatic drug–drug interactions. The aim of this work …

Neonatal Infections are among the most common reasons for admission to the intensive
care unit. Neonatal sepsis (NS) significantly contributes to mortality rates. Empiric antibiotic …

Infections are important factors contributing to the morbidity and mortality among elderly
patients. High rates of consumption of antimicrobial agents by the elderly may result in …

Aims Dicloxacillin is used to treat staphylococcal infections and we have previously shown
that dicloxacillin is an inducer of cytochrome P450 enzymes (CYPs). Here, we employed a …

Background The dysregulation of gut microbiota is pivotal in colorectal carcinogenesis.
Meanwhile, altered gut microbiome may affect the development of intestinal diseases …

Aims In patients of all ages, metamizole is a frequently used analgesic. Recently,
metamizole has been identified as an inducer of, among others, cytochrome P450 (CYP) 3A …

This study investigates the physicochemical interactions between fibrinogen (Fib), a key
glycoprotein in blood clotting, and a mixture of two biologically active compounds …

Flucloxacillin is a widely used antibiotic. It is an agonist to the nuclear receptor PXR that
regulates the expression of cytochrome P450 (CYP) enzymes. Treatment with flucloxacillin …