Functional characterization of DNA methylation in the oligodendrocyte lineage
Oligodendrocytes derive from progenitors (OPCs) through the interplay of epigenomic and
transcriptional events. By integrating high-resolution methylomics, RNA-sequencing, and …
transcriptional events. By integrating high-resolution methylomics, RNA-sequencing, and …
Prolonged Ezh2 depletion in glioblastoma causes a robust switch in cell fate resulting in tumor progression
EZH2 is frequently overexpressed in glioblastoma (GBM), suggesting an oncogenic function
that could be a target for therapeutic intervention. However, reduced EZH2 activity can also …
that could be a target for therapeutic intervention. However, reduced EZH2 activity can also …
Bioinspired nanofiber scaffold for differentiating bone marrow-derived neural stem cells to oligodendrocyte-like cells: design, fabrication, and characterization
F Rasti Boroojeni, S Mashayekhan… - International journal …, 2020 - Taylor & Francis
Background Researchers are trying to study the mechanism of neural stem cells (NSCs)
differentiation to oligodendrocyte-like cells (OLCs) as well as to enhance the selective …
differentiation to oligodendrocyte-like cells (OLCs) as well as to enhance the selective …
Regenerating the epigenome
MJ Barrero, JC Izpisua Belmonte - EMBO reports, 2011 - embopress.org
The ability of some organisms to regenerate parts of their body has fascinated scientists for
decades. The process of regeneration depends on the potential of certain cells to proliferate …
decades. The process of regeneration depends on the potential of certain cells to proliferate …
Retinoic-acid-mediated HRas stabilization induces neuronal differentiation of neural stem cells during brain development
Ras signaling is tightly regulated during neural stem cell (NSC) differentiation, and defects in
this pathway result in aberrant brain development. However, the mechanism regulating Ras …
this pathway result in aberrant brain development. However, the mechanism regulating Ras …
[HTML][HTML] Timing of the cell cycle exit of differentiating hippocampal neural stem cells
E Järvinen, A Angers-Loustau… - … journal of stem …, 2010 - synapse.koreamed.org
Neural stem cells contribute to mammalian brain tissue turnover in specific locations
throughout life. Differentiation of stem cells is associated with terminal mitosis and cell cycle …
throughout life. Differentiation of stem cells is associated with terminal mitosis and cell cycle …