The pathobiology of thrombosis, microvascular disease, and hemorrhage in the myeloproliferative neoplasms

HC Hasselbalch, M Elvers… - Blood, The Journal of the …, 2021 - ashpublications.org
Thrombotic, vascular, and bleeding complications are the most common causes of morbidity
and mortality in the Philadelphia chromosome–negative myeloproliferative neoplasms …

[HTML][HTML] Cardiovascular Risk in Philadelphia-Negative Myeloproliferative Neoplasms: Mechanisms and Implications—A Narrative Review

SB Todor, C Ichim, A Boicean, RG Mihaila - Current Issues in Molecular …, 2024 - mdpi.com
Myeloproliferative neoplasms (MPNs), encompassing disorders like polycythemia vera (PV),
essential thrombocythemia (ET), and primary myelofibrosis (PMF), are characterized by …

Current knowledge in pathophysiology and management of Budd-Chiari syndrome and non-cirrhotic non-tumoral splanchnic vein thrombosis

V Hernández-Gea, A De Gottardi, FWG Leebeek… - Journal of …, 2019 - Elsevier
Budd-Chiari syndrome and non-cirrhotic non-tumoral portal vein thrombosis are 2 rare
disorders, with several similarities that are categorized under the term splanchnic vein …

Distinct clinico-molecular arterial and venous thrombosis scores for myeloproliferative neoplasms risk stratification

H Pasquer, R Daltro de Oliveira, L Vasseur… - Leukemia, 2024 - nature.com
Current recommended risk scores to predict thrombotic events associated with
myeloproliferative neoplasms (MPN) do not discriminate between arterial and venous …

Clinical insights into the origins of thrombosis in myeloproliferative neoplasms

AR Moliterno, YZ Ginzburg… - Blood, The Journal of the …, 2021 - ashpublications.org
Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs), polycythemia
vera, essential thrombocythemia, and primary myelofibrosis, are hematopoietic stem cell …

JAK-STAT inhibition reduces endothelial prothrombotic activation and leukocyte–endothelial proadhesive interactions

JD Beckman, A DaSilva, E Aronovich, A Nguyen… - Journal of Thrombosis …, 2023 - Elsevier
Background Vascular activation is characterized by increased proinflammatory, pro
thrombotic, and proadhesive signaling. Several chronic and acute conditions, including Bcr …

Role of inflammation in the biology of myeloproliferative neoplasms

S Koschmieder, N Chatain - Blood reviews, 2020 - Elsevier
What is the role of inflammation in Myeloproliferative Neoplasms? This is currently a topic of
much debate. In this review, we will discuss experimental results and basic concepts of …

Thrombotic, inflammatory, and HIF-regulated genes and thrombosis risk in polycythemia vera and essential thrombocythemia

R Gangaraju, J Song, SJ Kim, T Tashi… - Blood …, 2020 - ashpublications.org
Thrombosis is a major cause of morbidity and mortality in polycythemia vera (PV) and
essential thrombocythemia (ET). The pathophysiology of thrombosis in these disorders …

Platelets as mediators of thromboinflammation in chronic myeloproliferative neoplasms

CP Marin Oyarzún, PG Heller - Frontiers in Immunology, 2019 - frontiersin.org
Chronic myeloproliferative neoplasms (MPN) are stem cell disorders driven by mutations in
JAK2, CALR, or MPL genes and characterized by myeloid proliferation and increased blood …

Pathogenesis and management of thrombotic disease in myeloproliferative neoplasms

DRJ Arachchillage, M Laffan - Seminars in Thrombosis and …, 2019 - thieme-connect.com
Chronic myeloproliferative neoplasms (MPN) are characterized by clonal expansion of an
abnormal hematopoietic stem/progenitor cell and include polycythemia vera (PV), essential …