Control of virulence gene expression in S. pyogenes is under the charge of 13 two-
component regulatory systems and at least 30 transcriptional regulators known thus far …

The two-component system VicRK and the orphan regulator CovR of Streptococcus mutans
co-regulate a group of virulence genes associated with the synthesis of and interaction with …

The c ontrol ofv irulence gene r egulator (CovR), also called c aspsule s ynthesis r egulator
(CsrR), is critical to how the major human pathogen group A Streptococcus fine-tunes …

The control of virulence regulator/sensor kinase (CovRS) two-component system is critical to
the infectivity of group A streptococcus (GAS), and CovRS inactivating mutations are …

Background Streptococcus dysgalactiae subspecies equisimilis (SDSE) is increasingly
recognized as an emerging cause of invasive diseases including necrotizing soft tissue …

Summary Group A Streptococcus (GAS) is a human-specific pathogen that evades the host
immune response through the elaboration of multiple virulence factors. Although many of …

Bacterial pathogens use cell surface‐associated adhesion molecules to promote host
attachment and colonization, and the ability to modulate adhesion expression is critical to …

Sequencing of invasive strains of group A streptococci (GAS) has revealed a diverse array of
single nucleotide polymorphisms in the gene encoding the c ontrol ofv irulence r egulator …

Streptococcus pyogenes, also known as group A Streptococcus, causes a wide variety of
diseases ranging from mild noninvasive to severe invasive infections. To identify possible …

A skin-tropic invasive group A Streptococcus pyogenes (GAS) strain, AP53, contains a
natural inactivating mutation in the covS gene (covS M) of the two-component responder …