Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation

SW Ryter, AMK Choi - Translational Research, 2016 - Elsevier
The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

Molecular physiology and pathophysiology of bilirubin handling by the blood, liver, intestine, and brain in the newborn

TWR Hansen, RJ Wong… - Physiological …, 2020 - journals.physiology.org
Bilirubin is the end product of heme catabolism formed during a process that involves
oxidation-reduction reactions and conserves iron body stores. Unconjugated …

Multiple genetic modifiers of bilirubin metabolism involvement in significant neonatal hyperbilirubinemia in patients of Chinese descent

H Yang, Q Wang, L Zheng, M Lin, X Zheng, F Lin… - PLoS …, 2015 - journals.plos.org
The potential for genetic variation to modulate neonatal hyperbilirubinemia risk is
increasingly being recognized. A case-control study was designed to assess comprehensive …

Roles of UGT1A1 Gly71Arg and TATA promoter polymorphisms in neonatal hyperbilirubinemia: A meta-analysis

J Wang, J Yin, M Xue, J Lyu, Y Wan - Gene, 2020 - Elsevier
Objective To identify the association between UGT1A1 Gly71Arg and TATA promoter
polymorphisms and neonatal hyperbilirubinemia. Methods The studies related to the …

Identification of Genetic Risk Factors for Neonatal Hyperbilirubinemia in Fujian Province, Southeastern China: A Case‐Control Study

J Zhou, C Yang, W Zhu, S Chen, Y Zeng… - BioMed Research …, 2018 - Wiley Online Library
To date, the genetic risk factors for neonatal hyperbilirubinemia remain unknown in
Southeastern China. This case‐control study aimed to identify the genetic risk factors for …

Risk assessment of prolonged jaundice in infants at one month of age: A prospective cohort study

YH Weng, SW Cheng, CY Yang, YW Chiu - Scientific reports, 2018 - nature.com
Prolonged jaundice is a commonly evaluated condition. The aim of this study was to assess
the risk factors of jaundice in healthy infants at one month of age. This prospective cohort …

Risk assessment of gene variants for neonatal hyperbilirubinemia in Taiwan

YH Weng, YW Chiu, SW Cheng, CY Yang - BMC pediatrics, 2016 - Springer
Background Hyperbilirubinemia is a common disorder during neonatal period in Taiwan.
Gene variants may play an important role in the development of neonatal …

Two faces of heme catabolic pathway in newborns: a potential role of bilirubin and carbon monoxide in neonatal inflammatory diseases

W Osiak, S Wątroba… - Oxidative medicine …, 2020 - Wiley Online Library
In an infant's body, all the systems undergo significant changes in order to adapt to the new,
extrauterine environment and challenges which it poses. Fragile homeostasis can be easily …

Effects of Gly71Arg mutation in UGT1A1 gene on neonatal hyperbilirubinemia: a systematic review and meta-analysis

H Mehrad-Majd, MS Haerian, J Akhtari… - The Journal of …, 2019 - Taylor & Francis
Abstract Objective: The associations between Gly71Arg polymorphism in the coding region
of uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene and the risk of …

High serum bilirubin is associated with lower prevalence of peripheral arterial disease among cardiac patients

M Ozeki, H Morita, M Miyamura, T Fujisaka, S Fujita… - Clinica chimica acta, 2018 - Elsevier
Several studies have shown that subjects with higher serum bilirubin may have a lower risk
of cardiovascular disorders. We herein investigated whether serum bilirubin concentration is …