Mitochondria-targeted triphenylphosphonium-based compounds: syntheses, mechanisms of action, and therapeutic and diagnostic applications
Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …
Rational design of nanocarriers for mitochondria-targeted drug delivery
L Huang, Z Sun, Q Shen, Z Huang, S Wang… - Chinese Chemical …, 2022 - Elsevier
Well-developed mitochondria-targeted nanocarriers for function regulation are highly
desirable. Numerous studies have been conducted on the treatment of mitochondria-related …
desirable. Numerous studies have been conducted on the treatment of mitochondria-related …
Structure‐guided design and synthesis of a mitochondria‐targeting near‐infrared fluorophore with multimodal therapeutic activities
X Tan, S Luo, L Long, Y Wang, D Wang… - Advanced …, 2017 - Wiley Online Library
An urgent challenge for imaging‐guided disease‐targeted multimodal therapy is to develop
the appropriate multifunctional agents to meet the requirements for potential applications …
the appropriate multifunctional agents to meet the requirements for potential applications …
Improvement of obesity-associated disorders by a small-molecule drug targeting mitochondria of adipose tissue macrophages
Y Wang, B Tang, L Long, P Luo, W Xiang, X Li… - Nature …, 2021 - nature.com
Pro-inflammatory activation of adipose tissue macrophages (ATMs) is causally linked to
obesity and obesity-associated disorders. A number of studies have demonstrated the …
obesity and obesity-associated disorders. A number of studies have demonstrated the …
Artemisinin and AIEgen conjugate for mitochondria-targeted and image-guided chemo-and photodynamic cancer cell ablation
Cell organelle targeting is a promising approach for cancer therapy. We herein report a light-
up probe (tetraphenylethenethiophene (TPETH)-Mito-1ART) to co-deliver artemisinin (ART) …
up probe (tetraphenylethenethiophene (TPETH)-Mito-1ART) to co-deliver artemisinin (ART) …
Mitochondrial targeting liposomes incorporating daunorubicin and quinacrine for treatment of relapsed breast cancer arising from cancer stem cells
Breast cancer stem cells play a crucial role in the relapse of breast cancers because they
are resistant to a standard chemotherapy and the residual cancer stem cells are able to …
are resistant to a standard chemotherapy and the residual cancer stem cells are able to …
Improving the phototherapeutic efficiencies of molecular and nanoscale materials by targeting mitochondria
Mitochondria-targeted cancer phototherapy (PT), which works by delivering
photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the …
photoresponsive agents specifically to mitochondria, is a powerful strategy to improve the …
Heptamethine cyanine dye mediated drug delivery: hype or hope
This review covers the application of heptamethine cyanine dye (HMCD) mediated drug
delivery. A relatively small number of HMCDs possess tumor targeting abilities, and this has …
delivery. A relatively small number of HMCDs possess tumor targeting abilities, and this has …
Dual-targeting nanosystem for enhancing photodynamic therapy efficiency
Photodynamic therapy (PDT) has been recognized as a valuable treatment option for
localized cancers. Herein, we demonstrate a cellular and subcellular targeted strategy to …
localized cancers. Herein, we demonstrate a cellular and subcellular targeted strategy to …
Photophysical, ion-sensing and biological properties of rhodamine-containing transition metal complexes
Rhodamine organic dyes have been known for years and have been applied in biological
studies because of numerous optical advantages, while rhodamine derivatives with spiro …
studies because of numerous optical advantages, while rhodamine derivatives with spiro …