Everyone ages, but only some will develop a neurodegenerative disorder in the process.
Disease might occur when cells fail to respond adaptively to age-related increases in …

In the vertebrate central nervous system, multipotential cells have been identified in vitro and
in vivo. Defined mitogens cause the proliferation of multipotential cells in vitro, the …

Importance Alzheimer disease (AD) is the most common neurodegenerative disorder and
lacks effective disease-modifying therapies. In 2001, we initiated a clinical trial of nerve …

Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

Cajal was probably the first neurobiologist to suggest that plasticity of nerve cells almost
completely disappeared during aging. However, we know today that neural plasticity is still …

In vitro expansion of central nervous system (CNS) precursors might overcome the limited
availability of dopaminergic neurons in transplantation for Parkinson's disease, but …

Intracranial transplantation of neural stem cells (NSCs) delayed disease onset, preserved
motor function, reduced pathology and prolonged survival in a mouse model of Sandhoff …

Neurotrophins have been intensively studied and have multiple roles in the brain.
Neurotrophins are first synthetized as proneurotrophins and then cleaved intracellularly and …

Here we summarize recent findings on the biology of hepatocyte growth factor (HGF, also
known as scatter factor), focusing on its effects on developing neurons. HGF is both a …

The effects of normal aging on the primate brain are incompletely understood. Although both
human and nonhuman primates demonstrate clear functional declines in selective …