Mechanisms of metabolism-coupled protein modifications

B Zhang, FC Schroeder - Nature Chemical Biology, 2025 - nature.com
Intricate coupling between metabolism and protein post-translational modifications (PTMs)
has emerged as a fundamental aspect of cellular regulation. Recent studies demonstrate …

An update on the metabolic landscape of oncogenic viruses

A Gaballah, B Bartosch - Cancers, 2022 - mdpi.com
Simple Summary Cancer cells amplify in an uncontrolled fashion. The resulting tumor and
metastases need to ensure their survival in the body. To achieve this, cancer cells display …

Hijacking of nucleotide biosynthesis and deamidation-mediated glycolysis by an oncogenic herpesvirus

Q Wan, L Tavakoli, TY Wang, AJ Tucker, R Zhou… - Nature …, 2024 - nature.com
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's
sarcoma (KS) and multiple types of B cell malignancies. Emerging evidence demonstrates …

[HTML][HTML] Translation factor accelerating peptide bond formation on the ribosome: EF-P and eIF5A as entropic catalysts and a potential drug targets

V Mudryi, F Peske, M Rodnina - BBA advances, 2023 - Elsevier
Abstract Elongation factor P (EF-P) and its eukaryotic homolog eIF5A are auxiliary
translation factors that facilitate peptide bond formation when several sequential proline …

Good cop, bad cop: Polyamines play both sides in host immunity and viral replication

YE Cruz-Pulido, BC Mounce - Seminars in Cell & Developmental Biology, 2023 - Elsevier
Viruses rely on host cells for energy and synthesis machinery required for genome
replication and particle assembly. Due to the dependence of viruses on host cells, viruses …

Hypusination in intestinal epithelial cells protects mice from infectious colitis

AP Gobert, CV Hawkins, KJ Williams, LA Snyder… - Gut …, 2024 - Taylor & Francis
Enteropathogenic Escherichia coli (EPEC) is a bacterium that causes attaching/effacing
(A/E) lesions and serious diarrheal disease, a major health issue in developing countries …

[HTML][HTML] Understanding Metabolic Pathway Rewiring by Oncogenic Gamma Herpesvirus

UY Choi, SH Lee - Journal of Microbiology and Biotechnology, 2024 - pmc.ncbi.nlm.nih.gov
Gamma herpesviruses, including Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated
herpesvirus (KSHV), are key contributors to the development of various cancers through …

Hepatitis C Virus Dysregulates Polyamine and Proline Metabolism and Perturbs the Urea Cycle

NF Zakirova, OA Khomich, OA Smirnova, J Molle… - Cells, 2024 - mdpi.com
Hepatitis C virus (HCV) is an oncogenic virus that causes chronic liver disease in more than
80% of patients. During the last decade, efficient direct-acting antivirals were introduced into …

METTL16 controls Kaposi's sarcoma-associated herpesvirus replication by regulating S-adenosylmethionine cycle

X Zhang, W Meng, J Feng, X Gao, C Qin, P Feng… - Cell Death & …, 2023 - nature.com
Oncogenic Kaposi's sarcoma-associated herpesvirus (KSHV) consists of latent and lytic
replication phases, both of which are important for the development of KSHV-related …

Mycobacterium dormancy and antibiotic tolerance within the retinal pigment epithelium of ocular tuberculosis

R Liu, JN Dang, R Lee, JJ Lee… - Microbiology …, 2024 - journals.asm.org
Tuberculosis (TB) is a leading cause of death among infectious diseases worldwide due to
latent TB infection, which is the critical step for the successful pathogenic cycle. In this stage …