There is a growing interest in realizing the benefits of continuous processing in biologics
manufacturing, which is reflected by the significant number of industrial and academic …

Rapid advances in intensifying upstream processes for biologics production have left
downstream processing as a bottleneck in the manufacturing scheme. Biomanufacturers are …

The biotechnology industry primarily uses batch technologies to manufacture recombinant
proteins. The natural evolution of other industries has shown that transitioning from batch to …

This paper presents a systems approach to evaluating the potential of integrated continuous
bioprocessing for monoclonal antibody (mAb) manufacture across a product's lifecycle from …

As continuous manufacturing of biotherapeutics gains steam, there is an increasing interest
in using machine learning (ML) techniques for real time prediction of product quality and for …

To maintain or strengthen their market position, biopharmaceutical producers have to adapt
their production facilities to a drastically changed market environment. Contrary to currently …

A twin-column counter-current chromatography processes, CaptureSMB, was used for the
protein A affinity capture of a monoclonal antibody (mAb). By means of sequential loading …

Continuous manufacturing is currently being seriously considered in the biopharmaceutical
industry as the possible new paradigm for producing therapeutic proteins, due to production …

Advances in fermentation technologies have resulted in the production of increased yields of
proteins of economic, biopharmaceutical, and medicinal importance. Consequently, there is …

For half a century aqueous two‐phase systems (ATPSs) have been applied for the extraction
and purification of biomolecules. In spite of their simplicity, selectivity, and relatively low cost …