The immune and skeletal systems share a variety of molecules, including cytokines,
chemokines, hormones, receptors, and transcription factors. Bone cells interact with immune …

The bone is an essential organ for locomotion and protection of the body, as well as
hematopoiesis and mineral homeostasis. In order to exert these functions throughout life …

Cancer-induced immune responses affect tumour progression and therapeutic response. In
multiple murine models and clinical datasets, we identified large variations of neutrophils …

Expansion of myeloid cells associated with solid tumor development is a key contributor to
neoplastic progression. Despite their clinical relevance, the mechanisms controlling myeloid …

Osteoclasts are derived from mononuclear hematopoietic myeloid lineage cells, which are
formed in the bone marrow and are attracted to the bloodstream by factors, including …

Bone homeostasis is securely controlled by the dynamic well‐balanced actions among
osteoclasts, osteoblasts and osteocytes. Osteoclasts are large multinucleated cells that …

In recent decades, the field of bone mechanobiology has sought experimental techniques to
unravel the molecular mechanisms governing the phenomenon of mechanically regulated …

Summary Interleukin 17 (IL-17)-mediated immunity plays a key role in protection from fungal
infections in mice and man. Here, we confirmed that mice deficient in the IL-17 receptor or …

Abstract Activating transcription factor 3 (ATF3) is a stress-responsive factor that belongs to
the activator protein 1 (AP-1) family of transcription factors. ATF3 expression is stimulated by …

Candida albicans can enter skeletal tissue through a skin wound in an
immunocompromised host or by contamination during orthopedic surgery. Such Candida …