Heritable variation in gene expression is common within and between species. This
variation arises from mutations that alter the form or function of molecular gene regulatory …

Scalable sequence–function studies have enabled the systematic analysis and cataloging of
hundreds of thousands of coding and noncoding genetic variants in the human genome …

Allosteric communication between distant sites in proteins is central to biological regulation
but still poorly characterized, limiting understanding, engineering and drug development …

Sequencing has revealed hundreds of millions of human genetic variants, and continued
efforts will only add to this variant avalanche. Insufficient information exists to interpret the …

Sequence logos are visually compelling ways of illustrating the biological properties of DNA,
RNA and protein sequences, yet it is currently difficult to generate and customize such logos …

INTRODUCTION Enzymes possess extraordinary catalytic proficiency and specificity. These
properties ultimately derive from interactions not just between the active-site residues and …

Predicting the thermodynamic stability of proteins is a common and widely used step in
protein engineering, and when elucidating the molecular mechanisms behind evolution and …

Engineered RNA elements are programmable tools capable of detecting small molecules,
proteins, and nucleic acids. Predicting the behavior of these synthetic biology components …

Conspectus Over just the last 2 years, mRNA therapeutics and vaccines have undergone a
rapid transition from an intriguing concept to real-world impact. However, whereas some …

There are more ways to synthesize a 100-amino acid (aa) protein (20100) than there are
atoms in the universe. Only a very small fraction of such a vast sequence space can ever be …