Alzheimer's disease (AD) is considered a polygenic disorder. This view is clouded, however,
by lingering uncertainty over how to treat the quasi" monogenic" role of apolipoprotein E …

The past two centuries have witnessed an unprecedented rise in human life expectancy.
Sustaining longer lives with reduced periods of disability will require an understanding of the …

Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide.
Although genome-wide association studies have identified PAU risk genes, the genetic …

Results from genome-wide association studies (GWAS) can be used to infer causal
relationships between phenotypes, using a strategy known as 2-sample Mendelian …

Frailty is a common geriatric syndrome and strongly associated with disability, mortality and
hospitalization. Frailty is commonly measured using the frailty index (FI), based on the …

Although systemic diseases take the biggest toll on human health and well-being,
increasingly, a failing brain is the arbiter of a death preceded by a gradual loss of the …

We use a genome-wide association of 1 million parental lifespans of genotyped subjects
and data on mortality risk factors to validate previously unreplicated findings near CDKN2B …

Major depressive disorder (MDD) is a common illness accompanied by considerable
morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide …

Human DNA polymorphisms vary across geographic regions, with the most commonly
observed variation reflecting distant ancestry differences. Here we investigate the …