200 billion red blood cells (RBCs) are produced every day, requiring more than 2× 10 15
iron atoms every second to maintain adequate erythropoiesis. These numbers translate into …

Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …

Iron homeostasis is essential for health; moreover, hepcidin-deficiency results in iron
overload in both hereditary hemochromatosis and iron-loading anemia. Here, we identified …

Ferroptosis is a recently identified iron‐dependent form of nonapoptotic cell death implicated
in brain, kidney, and heart pathology. However, the biological roles of iron and iron …

The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …

Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

Iron is required for many biological processes but is also toxic in excess; thus, body iron
balance is maintained through sophisticated regulatory mechanisms. The lack of a regulated …

The iron hormone hepcidin and its receptor and cellular iron exporter ferroportin control the
major fluxes of iron into blood plasma: intestinal iron absorption, the delivery of recycled iron …

Iron is an essential dietary element. However, the ability of iron to cycle between oxidized
and reduced forms also renders it capable of contributing to free radical formation, which …

Ferroptosis is a novel type of programmed cell death, characterized by a dysregulated iron
metabolism and accumulation of lipid peroxides. It features the alteration of mitochondria …